Publications

Freville A, Stewart L.B, Tetteh K.K.A, Treeck M, Cortes A, Voss T.S, Tarr S.J, Baker D.A, Conway D.J. Expression of the MSPDBL2 antigen in a discrete subset of Plasmodium falciparum schizonts is regulated by GDV1 but may not be linked to sexual commitment. mBio. 2024;15(5):e0314023. DOI: 10.1128/mbio.03140-23

Voss T.S, Brancucci N.M. Regulation of sexual commitment in malaria parasites - a complex affair. Curr Opin Microbiol. 2024;79:102469. DOI: 10.1016/j.mib.2024.102469

Wyss M, Kanyal A, Niederwieser I, Bartfai R, Voss T.S. The Plasmodium falciparum histone methyltransferase PfSET10 is dispensable for the regulation of antigenic variation and gene expression in blood-stage parasites. mSphere. 2024(in press). DOI: 10.1128/msphere.00546-24

Wyss M, Thommen B.T, Kofler J, Carrington E, Brancucci N.M.B, Voss T.S. The three Plasmodium falciparum Aurora-related kinases display distinct temporal and spatial associations with mitotic structures in asexual blood stage parasites and gametocytes. mSphere. 2024;9(9):e0046524. DOI: 10.1128/msphere.00465-24

Gockel J, Voss T.S, Bártfai R. The troubled puberty of malaria parasites. Trends Parasitol. 2023;39(3):155-157. DOI: 10.1016/j.pt.2023.01.006

Kuehnel R.M, Ganga E, Balestra A.C, Suarez C, Wyss M, Klages N, Brusini L, Maco B, Brancucci N, Voss T.S, Soldati D, Brochet M. A Plasmodium membrane receptor platform integrates cues for egress and invasion in blood forms and activation of transmission stages. Sci Adv. 2023;9(24):eadf2161. DOI: 10.1126/sciadv.adf2161

Meier L, Antillón M, Burri C, Chitnis N, Endriss Y, Keiser J, Moore S, Müller P, Penny M, Voss T.S, Mäser P, Utzinger J. Repurposing know-how for drug development: case studies from the Swiss Tropical and Public Health Institute. Chimia (Aarau). 2023;77(9):582-592. DOI: 10.2533/chimia.2023.582

Stewart L.B, Freville A, Voss T.S, Baker D.A, Awandare G.A, Conway D.J. Plasmodium falciparum sexual commitment rate variation among clinical isolates and diverse laboratory-adapted lines. Microbiol Spectr. 2022;10(6):e0223422. DOI: 10.1128/spectrum.02234-22

Thommen B.T, Passecker A, Buser T, Hitz E, Voss T.S, Brancucci N.M.B. Revisiting the effect of pharmaceuticals on transmission stage formation in the malaria parasite Plasmodium falciparum. Front Cell Infect Microbiol. 2022;12:802341. DOI: 10.3389/fcimb.2022.802341

Boltryk S.D, Passecker A, Alder A, Carrington E, van de Vegte-Bolmer M, van Gemert G.J, van der Starre A, Beck H.P, Sauerwein R.W, Kooij T.W.A, Brancucci N.M.B, Proellochs N.I, Gilberger T.W, Voss T.S. CRISPR/Cas9-engineered inducible gametocyte producer lines as a valuable tool for Plasmodium falciparum malaria transmission research. Nat Commun. 2021;12:4806. DOI: 10.1038/s41467-021-24954-4

Bui H.T.N, Passecker A, Brancucci N.M.B, Voss T.S. Investigation of heterochromatin protein 1 function in the malaria parasite Plasmodium falciparum using a conditional domain deletion and swapping approach. mSphere. 2021;6(1):e01220-20. DOI: 10.1128/mSphere.01220-20

Carrington E, Cooijmans R.H.M, Keller D, Toenhake C.G, Bartfai R, Voss T.S. The ApiAP2 factor PfAP2-HC is an integral component of heterochromatin in the malaria parasite Plasmodium falciparum. iScience. 2021;24(5):102444. DOI: 10.1016/j.isci.2021.102444

Evers F, Cabrera-Orefice A, Elurbe D.M, Kea-Te Lindert M, Boltryk S.D, Voss T.S, Huynen M.A, Brandt U, Kooij T.W.A. Composition and stage dynamics of mitochondrial complexes in Plasmodium falciparum. Nat Commun. 2021;12:3820. DOI: 10.1038/s41467-021-23919-x

Hitz E, Grüninger O, Passecker A, Wyss M, Scheurer C, Wittlin S, Beck H.P, Brancucci N.M.B, Voss T.S. The catalytic subunit of Plasmodium falciparum casein kinase 2 is essential for gametocytogenesis. Commun Biol. 2021;4(1):336. DOI: 10.1038/s42003-021-01873-0

Hitz E, Wiedemar N, Passecker A, Graça B.A.S, Scheurer C, Wittlin S, Brancucci N.M.B, Vakonakis I, Mäser P, Voss T.S. The 3-phosphoinositide-dependent protein kinase 1 is an essential upstream activator of protein kinase A in malaria parasites. PLoS Biol. 2021;19(12):e3001483. DOI: 10.1371/journal.pbio.3001483

Tibúrcio M, Hitz E, Niederwieser I, Kelly G, Davies H, Doerig C, Billker O, Voss T.S, Treeck M. A 39-amino-acid C-terminal truncation of GDV1 disrupts sexual commitment in Plasmodium falciparum. mSphere. 2021;6(3):e01093-20. DOI: 10.1128/mSphere.01093-20

Giovanoli Evack J, Schmidt R.S, Boltryk S.D, Voss T.S, Batil A.A, Ngandolo B.N, Greter H, Utzinger J, Zinsstag J, Balmer O. Molecular confirmation of a Fasciola gigantica x Fasciola hepatica hybrid in a Chadian bovine. J Parasitol. 2020;106(2):316-322. DOI: 10.1645/19-66

Hitz E, Balestra A.C, Brochet M, Voss T.S. PfMAP-2 is essential for male gametogenesis in the malaria parasite Plasmodium falciparum. Sci Rep. 2020;10:11930. DOI: 10.1038/s41598-020-68717-5

Warncke J.D, Passecker A, Kipfer E, Brand F, Perez-Martinez L, Proellochs N.I, Kooij T.W.A, Butter F, Voss T.S, Beck H.P. The PHIST protein GEXP02 targets the host cytoskeleton during sexual development of Plasmodium falciparum. Cell Microbiol. 2020;22(2):e13123. DOI: 10.1111/cmi.13123

Bui H.T.N, Niederwieser I, Bird M.J, Dai W, Brancucci N.M.B, Moes S, Jenoe P, Lucet I.S, Doerig C, Voss T.S. Mapping and functional analysis of heterochromatin protein 1 phosphorylation in the malaria parasite Plasmodium falciparum. Sci Rep. 2019;9:16720. DOI: 10.1038/s41598-019-53325-9

Brancucci N.M.B, De Niz M, Straub T.J, Ravel D, Sollelis L, Birren B.W, Voss T.S, Neafsey D.E, Marti M. Probing Plasmodium falciparum sexual commitment at the single-cell level. Wellcome Open Res. 2018;3:70. DOI: 10.12688/wellcomeopenres.14645.3

Filarsky M, Fraschka S.A, Niederwieser I, Brancucci N.M.B, Carrington E, Carrió E, Moes S, Jenoe P, Bartfai R, Voss T.S. GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing. Science. 2018;359(6381):1259-1263. DOI: 10.1126/science.aan6042

Fraschka S.A, Filarsky M, Hoo R, Niederwieser I, Yan Yam X, Brancucci N.M.B, Mohring F, Mushunje A.T, Huang X, Christensen P.R, Nosten F, Bozdech Z, Russell B, Moon R.W, Marti M, Preiser P.R, Bártfai R, Voss T.S. Comparative heterochromatin profiling reveals conserved and unique epigenome signatures linked to adaptation and development of malaria parasites. Cell Host Microbe. 2018;23(3):407-420 e8. DOI: 10.1016/j.chom.2018.01.008

Meerstein-Kessel L, Andolina C, Carrió E, Mahamar A, Sawa P, Diawara H, van de Vegte-Bolmer M, Stone W, Collins K.A, Schneider P, Dicko A, Drakeley C, Felger I, Voss T, Lanke K, Bousema T. A multiplex assay for the sensitive detection and quantification of male and female Plasmodium falciparum gametocytes. Malar J. 2018;17:441. DOI: 10.1186/s12936-018-2584-y

Zhu L, Tripathi J, Rocamora F.M, Miotto O, van der Pluijm R, Voss T.S, Mok S, Kwiatkowski D.P, Nosten F, Day N.P.J, White N.J, Dondorp A.M, Bozdech Z, Tracking Resistance to Artemisinin Collaboration I. The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background. Nat Commun. 2018;9(1):5158. DOI: 10.1038/s41467-018-07588-x

Bertschi N.L, Toenhake C.G, Zou A, Niederwieser I, Henderson R, Moes S, Jenoe P, Parkinson J, Bartfai R, Voss T.S. Malaria parasites possess a telomere repeat-binding protein that shares ancestry with transcription factor IIIA. Nat Microbiol. 2017;2:17033. DOI: 10.1038/nmicrobiol.2017.33

Brancucci N.M.B, Gerdt J.P, Wang C, De Niz M, Philip N, Adapa S.R, Zhang M, Hitz E, Niederwieser I, Boltryk S.D, Laffitte M.C, Clark M.A, Gruring C, Ravel D, Blancke Soares A, Demas A, Bopp S, Rubio-Ruiz B, Conejo-Garcia A, Wirth D.F, Gendaszewska-Darmach E, Duraisingh M.T, Adams J.H, Voss T.S, Waters A.P, Jiang R.H.Y, Clardy J, Marti M. Lysophosphatidylcholine regulates sexual stage differentiation in the human malaria parasite Plasmodium falciparum. Cell. 2017;171(7):1532-1544 e15. DOI: 10.1016/j.cell.2017.10.020

Ngwa C.J, Kiesow M.J, Papst O, Orchard L.M, Filarsky M, Rosinski A.N, Voss T.S, Llinas M, Pradel G. Transcriptional profiling defines histone acetylation as a regulator of gene expression during human-to-mosquito transmission of the malaria parasite Plasmodium falciparum. Front Cell Infect Microbiol. 2017;7:320. DOI: 10.3389/fcimb.2017.00320

Josling G.A, Petter M, Oehring S.C, Gupta A.P, Dietz O, Wilson D.W, Schubert T, Langst G, Gilson P.R, Crabb B.S, Moes S, Jenoe P, Lim S.W, Brown G.V, Bozdech Z, Voss T.S, Duffy M.F. A Plasmodium falciparum bromodomain protein regulates invasion gene expression. Cell Host Microbe. 2015;17(6):741-751. DOI: 10.1016/j.chom.2015.05.009

Pelle K.G, Oh K, Buchholz K, Narasimhan V, Joice R, Milner D.A, Brancucci N.M, Ma S, Voss T.S, Ketman K, Seydel K.B, Taylor T.E, Barteneva N.S, Huttenhower C, Marti M. Transcriptional profiling defines dynamics of parasite tissue sequestration during malaria infection. Genome Med. 2015;7:19. DOI: 10.1186/s13073-015-0133-7

Brancucci N.M, Bertschi N.L, Zhu L, Niederwieser I, Chin W.H, Wampfler R, Freymond C, Rottmann M, Felger I, Bozdech Z, Voss T.S. Heterochromatin protein 1 secures survival and transmission of malaria parasites. Cell Host Microbe. 2014;16(2):165-176. DOI: 10.1016/j.chom.2014.07.004

Brancucci N.M, Witmer K, Schmid C, Voss T.S. A var gene upstream element controls protein synthesis at the level of translation initiation in Plasmodium falciparum. PLoS One. 2014;9(6):e100183. DOI: 10.1371/journal.pone.0100183

Dietz O, Rusch S, Brand F, Mundwiler-Pachlatko E, Gaida A, Voss T, Beck H.P. Characterization of the small exported Plasmodium falciparum membrane protein SEMP1. PLoS One. 2014;9(7):e103272. DOI: 10.1371/journal.pone.0103272

Voss T.S, Bozdech Z, Bartfai R. Epigenetic memory takes center stage in the survival strategy of malaria parasites. Curr Opin Microbiol. 2014;20:88-95. DOI: 10.1016/j.mib.2014.05.007

Brunner R, Ng C.L, Aissaoui H, Akabas M.H, Boss C, Brun R, Callaghan P.S, Corminboef O, Frame I.J, Heidmann B, Le Bihan A, Jenö P, Mattheis C, Moes S, Müller I.B, Paguio M, Roepe P.D, Siegrist R, Voss T, Welford R.W, Wittlin S, Fidock D.A, Binkert C. UV-triggered affinity-capture identifies interactions between the Plasmodium falciparum multidrug resistance protein 1 (PfMDR1) and antimalarial agents in live parasitized cells. J Biol Chem. 2013;288(31):22576-22583. DOI: 10.1074/jbc.M113.453159

Brancucci N.M, Witmer K, Schmid C.D, Flueck C, Voss T.S. Identification of a cis-acting DNA-protein interaction implicated in singular var gene choice in Plasmodium falciparum. Cell Microbiol. 2012;14(12):1836-1848. DOI: 10.1111/cmi.12004

Brunner R, Aissaoui H, Boss C, Bozdech Z, Brun R, Corminboeuf O, Delahaye S, Fischli C, Heidmann B, Kaiser M, Kamber J, Meyer S, Papastogiannidis P, Siegrist R, Voss T, Welford R, Wittlin S, Binkert C. Identification of a new chemical class of antimalarials. J Infect Dis. 2012;206(5):735-743. DOI: 10.1093/infdis/jis418

Cortés A, Crowley V.M, Vaquero A, Voss T.S. A view on the role of epigenetics in the biology of malaria parasites. PLoS Pathog. 2012;8(12):e1002943. DOI: 10.1371/journal.ppat.1002943

Dreyer A.M, Matile H, Papastogiannidis P, Kamber J, Favuzza P, Voss T.S, Wittlin S, Pluschke G. Passive immunoprotection of Plasmodium falciparum-infected mice designates the CyRPA as candidate malaria vaccine antigen. J Immunol. 2012;188(12):6225-6237. DOI: 10.4049/jimmunol.1103177

Hoeijmakers W.A, Flueck C, Françoijs K.J, Smits A.H, Wetzel J, Volz J.C, Cowman A.F, Voss T, Stunnenberg H.G, Bártfai R. Plasmodium falciparum centromeres display a unique epigenetic makeup and cluster prior to and during schizogony. Cell Microbiol. 2012;14(9):1391-1401. DOI: 10.1111/j.1462-5822.2012.01803.x

Oehring S.C, Woodcroft B.J, Moes S, Wetzel J, Dietz O, Pulfer A, Dekiwadia C, Mäser P, Flück C, Witmer K, Brancucci N.M, Niederwieser I, Jenoe P, Ralph S.A, Voss T.S. Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite Plasmodium falciparum. Genome Biol. 2012;13(11):R108. DOI: 10.1186/gb-2012-13-11-r108

Witmer K, Schmid C.D, Brancucci N.M, Luah Y.H, Preiser P.R, Bozdech Z, Voss T.S. Analysis of subtelomeric virulence gene families in Plasmodium falciparum by comparative transcriptional profiling. Mol Microbiol. 2012;84(2):243-259. DOI: 10.1111/j.1365-2958.2012.08019.x

Flueck C, Bartfai R, Niederwieser I, Witmer K, Alako B.T, Moes S, Bozdech Z, Jenoe P, Stunnenberg H.G, Voss T.S. A major role for the Plasmodium falciparum ApiAP2 protein PfSIP2 in chromosome end biology. PLoS Pathog. 2010;6(2):e1000784. DOI: 10.1371/journal.ppat.1000784

Flueck C, Bartfai R, Volz J, Niederwieser I, Salcedo-Amaya A.M, Alako B.T, Ehlgen F, Ralph S.A, Cowman A.F, Bozdech Z, Stunnenberg H.G, Voss T.S. Plasmodium falciparum heterochromatin protein 1 marks genomic loci linked to phenotypic variation of exported virulence factors. PLoS Pathog. 2009;5(9):e1000569. DOI: 10.1371/journal.ppat.1000569

Tonkin C.J, Carret C.K, Duraisingh M.T, Voss T.S, Ralph S.A, Hommel M, Duffy M.F, Silva L.M, Scherf A, Ivens A, Speed T.P, Beeson J.G, Cowman A.F. Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum. PLoS Biol. 2009;7(4):e84. DOI: 10.1371/journal.pbio.1000084

Treeck M, Tamborrini M, Daubenberger C.A, Gilberger T.W, Voss T.S. Caught in action: mechanistic insights into antibody-mediated inhibition of Plasmodium merozoite invasion. Trends Parasitol. 2009;25(11):494-497. DOI: 10.1016/j.pt.2009.07.008

Llinas M, Deitsch K.W, Voss T.S. Plasmodium gene regulation: far more to factor in. Trends Parasitol. 2008;24(12):551-556. DOI: 10.1016/j.pt.2008.08.010

D'Ombrain M.C, Voss T.S, Maier A.G, Pearce J.A, Hansen D.S, Cowman A.F, Schofield L. Plasmodium falciparum erythrocyte membrane protein-1 specifically suppresses early production of host interferon-gamma. Cell Host Microbe. 2007;2(2):130-138. DOI: 10.1016/j.chom.2007.06.012

Elliott S.R, Spurck T.P, Dodin J.M, Maier A.G, Voss T.S, Yosaatmadja F, Payne P.D, McFadden G.I, Cowman A.F, Rogerson S.J, Schofield L, Brown G.V. Inhibition of dendritic cell maturation by malaria is dose dependent and does not require Plasmodium falciparum erythrocyte membrane protein 1. Infect Immun. 2007;75(7):3621-3632. DOI: 10.1128/IAI.00095-07

Voss T.S, Tonkin C.J, Marty A.J, Thompson J.K, Healer J, Crabb B.S, Cowman A.F. Alterations in local chromatin environment are involved in silencing and activation of subtelomeric var genes in Plasmodium falciparum. Mol Microbiol. 2007;66(1):139-150. DOI: 10.1111/j.1365-2958.2007.05899.x

Marty A.J, Thompson J.K, Duffy M.F, Voss T.S, Cowman A.F, Crabb B.S. Evidence that Plasmodium falciparum chromosome end clusters are cross-linked by protein and are the sites of both virulence gene silencing and activation. Mol Microbiol. 2006;62(1):72-83. DOI: 10.1111/j.1365-2958.2006.05364.x

Voss T.S, Healer J, Marty A.J, Duffy M.F, Thompson J.K, Beeson J.G, Reeder J.C, Crabb B.S, Cowman A.F. A var gene promoter controls allelic exclusion of virulence genes in Plasmodium falciparum malaria. Nature. 2006;439(7079):1004-1008. DOI: 10.1038/nature04407

Duraisingh M.T, Voss T.S, Marty A.J, Duffy M.F, Good R.T, Thompson J.K, Freitas-Junior L.H, Scherf A, Crabb B.S, Cowman A.F. Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum. Cell. 2005;121(1):13-24. DOI: 10.1016/j.cell.2005.01.036

Voss T.S, Kaestli M, Vogel D, Bopp S, Beck H.P. Identification of nuclear proteins that differentially interact with Plasmodium falciparum var gene promoters. Mol Microbiol. 2003;48(6):1593-1607

Voss T.S, Mini T, Jenoe P, Beck H.P. Plasmodium falciparum possesses a cell-cycle regulated short-type replication protein: a large subunit encodet by an unusual transcript. J Biol Chem. 2003;277(20):17493-17501

Voss T. Extraction and purification of Plasmodium total RNA. Methods Mol Med. 2002;72:151-157. DOI: 10.1385/1-59259-271-6:151

Voss Till S. Investigation of molecular mechanism underlying variant antigen gene expression in Plasmodium falciparum. Basel: Univ. Basel, 2002. Doctoral Thesis, University of Basel, Faculty of Science

Voss T.S, Thompson J.K, Waterkeyn J, Felger I, Weiss N, Cowman A.F, Beck H.P. Genomic distribution and functional characterisation of two distinct and conserved Plasmodium falciparum var gene 5' flanking sequences. Mol Biochem Parasitol. 2000;107(1):103-115