Total synthesis and antitrypanosomal activity of janadolide and simplified analogues (Publications)
Janadolide is a cyclic depsipeptide natural product isolated from the marine cyanobacterium Okeania sp. Herein, we describe the total synthesis of janadolide, along with eight simplified analogues, vi
Health and economic burden of respiratory syncytial virus (RSV) disease and the cost-effectiveness of potential interventions against RSV among... (Publications)
BACKGROUND: Respiratory syncytial virus (RSV) frequently causes acute lower respiratory infection in children under 5, representing a high burden in Gavi-eligible countries (mostly low-income and lowe
Re-annotation of the <em>Theileria parva</em> genome refines 53% of the proteome and uncovers essential components of N-glycosylation, a conserved... (Publications)
BACKGROUND: The apicomplexan parasite Theileria parva causes a livestock disease called East coast fever (ECF), with millions of animals at risk in sub-Saharan East and Southern Africa, the geographic
Mechanochemical formation of racemic praziquantel hemihydrate with improved biopharmaceutical properties (Publications)
Praziquantel (PZQ) is the first-line drug used against schistosomiasis, one of the most common parasitic diseases in the world. A series of crystalline structures including two new polymorphs of the p
Association between the proportion of <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> infections detected by passive surveillance and the... (Publications)
BACKGROUND: Passively collected malaria case data are the foundation for public health decision making. However, because of population-level immunity, infections might not always be sufficiently sympt
Financial support to medicaid-eligible mothers increases caregiving for preterm infants (Publications)
OBJECTIVES: To assess the impact of financial support on maternal caregiving activities for preterm infants. METHODS: We conducted a small randomized controlled trial (RCT) in two Massachusetts Neonat
Early life risk factors of motor, cognitive and language development: a pooled analysis of studies from low/middle-income countries (Publications)
OBJECTIVE: To determine the magnitude of relationships of early life Ffactors with child development in low/middle-income countries (LMICs). DESIGN: Meta-analyses of standardised mean differences (SMD
An African origin for<em> Mycobacterium bovis</em> (Publications)
Background and objectives: Mycobacterium bovis and Mycobacterium caprae are two of the most important agents of tuberculosis in livestock and the most important causes of zoonotic tuberculosis in huma
microRNA expression profiles and personal monitoring of exposure to particulate matter (Publications)
An increasing number of findings from epidemiological studies support associations between exposure to air pollution and the onset of several diseases, including pulmonary, cardiovascular and neurodeg
Health systems and global progress towards malaria elimination, 2000-2016 (Publications)
BACKGROUND: As more countries progress towards malaria elimination, a better understanding of the most critical health system features for enabling and supporting malaria control and elimination is ne