Total synthesis and biological investigation of (-)-artemisinin: the antimalarial activity of artemisinin is not stereospecific (Publications)
Here, we describe an efficient and diversity oriented entry to both (-)-artemisinin (1) and to its natural antipode (+)-artemisinin starting from commercially and readily available S-(+)- and R-(-)-ci
Sedentary behaviour in Swiss children and adolescents: disentangling associations with the perceived and objectively measured environment (Publications)
Identifying correlates of sedentary behaviour across all levels of the ecological model and understanding their interrelations is a promising method to plan effective interventions. The present study
2<em>H</em>-1,2,3-triazole-based dipeptidyl nitriles: potent, selective, and trypanocidal rhodesain inhibitors by structure-based design (Publications)
Macrocyclic inhibitors of rhodesain (RD), a parasitic cysteine protease and drug target for the treatment of human African trypanosomiasis, have shown low metabolic stability at the macrocyclic ether
Quantifying human-environment interactions using videography in the context of infectious disease transmission (Publications)
Quantitative data on human-environment interactions are needed to fully understand infectious disease transmission processes and conduct accurate risk assessments. Interaction events occur during an i
First report of human intestinal sarcocystosis in Cambodia (Publications)
Human intestinal sarcocystosis (HIS), caused by Sarcocystis species, is acquired by eating undercooked meat from sarcocyst-containing cattle (S. hominis, S. heydorni) and pigs (S. suihominis). We repo
The development of an ivermectin-based attractive toxic sugar bait (ATSB) to target <em>Anopheles arabiensis</em> (Publications)
BACKGROUND: An increasing number of countries in sub-Saharan Africa are moving towards malaria-elimination, mostly thanks to successful vector control campaigns. However, elimination has proven challe
Patient-centered boundary mechanisms to foster intercultural partnerships in health care: a case study in Guatemala (Publications)
BACKGROUND: Up to one half of the population in Africa, Asia and Latin America has little access to high-quality biomedical services and relies on traditional health systems. Medical pluralism is thus
Short-term association between ambient air pollution and pneumonia in children: a systematic review and meta-analysis of time-series and... (Publications)
Ambient air pollution has been associated with respiratory diseases in children. However, its effects on pediatric pneumonia have not been meta-analyzed. We conducted a systematic review and meta-anal
Automated high throughput analysis of antiretroviral drugs in dried blood spots (Publications)
For therapeutic drug monitoring (TDM) in remote settings, dried blood spots (DBS) are particularly advantageous, as blood sample collection and handling is uncomplicated. The aim of this study was to