Malaria infection in mosquitoes decreases the personal protection offered by permethrin-treated bednets (Publications)
BACKGROUND: Insecticides targeting adult mosquitoes are the main way of controlling malaria. They work not only by killing mosquitoes, but also by repelling and irritating them. Indeed their repellent
Interplay of strain and race/ethnicity in the innate immune response to <em>M. tuberculosis</em> (Publications)
BACKGROUND: The roles of host and pathogen factors in determining innate immune responses to M. tuberculosis are not fully understood. In this study, we examined host macrophage immune responses of 3
Identification of fast-acting 2,6-disubstituted imidazopyridines that are efficacious in the <em>In Vivo</em> humanized <em>Plasmodium falciparum</em>... (Publications)
Optimization of a chemical series originating from whole-cell phenotypic screening against the human malaria parasite, Plasmodium falciparum, led to the identification of two promising 2,6-disubstitut
UCT943, a next generation <em>Plasmodium falciparum</em> PI4K inhibitor preclinical candidate for the treatment of malaria (Publications)
The 2-aminopyridine MMV048 was the first drug candidate inhibiting Plasmodium phosphatidylinositol 4-kinase (PI4K), a novel drug target for malaria, to enter clinical development. In an effort to iden
A prospective cohort study of school-going children investigating reproductive and neurobehavioral health effects due to environmental pesticide... (Publications)
BACKGROUND: Research on reproductive health effects on children from low-level, long-term exposure to pesticides currently used in the agricultural industry is limited and those on neurobehavioral eff
Response of cord blood cells to environmental, hereditary and perinatal factors: a prospective birth cohort study (Publications)
BACKGROUND: Many studies investigating the impact of individual risk factors on cord blood immune cell counts may be biased given that cord blood composition is influenced by a multitude of factors. T