Temporal variation of pesticide mixtures in rivers of three agricultural watersheds during a major drought in the Western Cape, South Africa (Publications)
South Africa is the leading pesticide user in Sub-Saharan Africa. However, little is known about the occurrence of pesticide mixtures in surface water and potential environmental risks in Africa. This
"Because at school, you can become somebody" - the perceived health and economic returns on secondary schooling in rural Burkina Faso (Publications)
BACKGROUND: The perceived returns on schooling are critical in schooling decision-making but are not well understood. This study examines the perceived returns on secondary schooling in Burkina Faso,
Screening strategies for a sustainable endpoint for <em>gambiense </em>sleeping sickness (Publications)
BACKGROUND: Gambiense human African trypanosomiasis ([gHAT] sleeping sickness) is a vector-borne disease that is typically fatal without treatment. Intensified, mainly medical-based, interventions in
Comparison of next-generation portable pollution monitors to measure exposure to PM2.5 from household air pollution in Puno, Peru (Publications)
Assessment of personal exposure to PM2.5 is critical for understanding intervention effectiveness and exposure-response relationships in household air pollution studies. In this pilot study, we compar
Ensuring transmission through dynamic host environments: host-pathogen interactions in <em>Plasmodium </em>sexual development (Publications)
A renewed global commitment to malaria elimination lends urgency to understanding the biology of Plasmodium transmission stages. Recent progress toward uncovering the mechanisms underlying Plasmodium
Sex: how malaria parasites get turned on (Publications)
The mechanisms underlying sexual stage switching in Plasmodium spp. have hitherto remained a mystery. However, two recent studies have revealed that an apicomplexan-specific DNA-binding protein is ess
An assay to probe <em>Plasmodium falciparum</em> growth, transmission stage formation and early gametocyte development (Publications)
Conversion from asexual proliferation to sexual differentiation initiates the production of the gametocyte, which is the malaria parasite stage required for human-to-mosquito transmission. This protoc
Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria (Publications)
Malaria remains one of the greatest public health challenges worldwide, particularly in sub-Saharan Africa. The clinical outcome of individuals infected with Plasmodium falciparum parasites depends on
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors (Publications)
Antimalarial drugs have thus far been chiefly derived from two sources-natural products and synthetic drug-like compounds. Here we investigate whether antimalarial agents with novel mechanisms of acti