Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function (Publications)
BACKGROUND: Genome-wide association studies (GWAS) have identified numerous loci influencing cross-sectional lung function, but less is known about genes influencing longitudinal change in lung functi
Interaction between gas cooking and GSTM1 null genotype in bronchial responsiveness: results from the European Community Respiratory Health Survey (Publications)
BACKGROUND: Increased bronchial responsiveness is characteristic of asthma. Gas cooking, which is a major indoor source of the highly oxidant nitrogen dioxide, has been associated with respiratory sym
Causal and synthetic associations of variants in the SERPINA gene cluster with alpha1-antitrypsin serum levels (Publications)
Several infrequent genetic polymorphisms in the SERPINA1 gene are known to substantially reduce concentration of alpha1-antitrypsin (AAT) in the blood. Since low AAT serum levels fail to protect pulmo
Human leukocyte antigen class II variants and adult-onset asthma: does occupational allergen exposure play a role? (Publications)
Recently, a locus centred on rs9273349 in the HLA-DQ region emerged from genome-wide association studies of adult-onset asthma. We aimed to further investigate the role of human leukocyte antigen (HLA
Interactions between SERPINA1 PiMZ genotype, occupational exposure and lung function decline (Publications)
OBJECTIVES: We evaluated interactions between SERPINA1 PiMZ genotype, associated with intermediate alpha1-antitrysin deficiency, with outdoor particulate matter
Sleep fragmentation and sleep-disordered breathing in individuals living close to main roads: results from a population-based study (Publications)
BACKGROUND: Nighttime traffic noise is associated with sleep disturbances, but sleep fragmentation and sleep-disordered breathing (SDB) have not been demonstrated in individuals living near busy roads
Sensitisation to Ambrosia in Switzerland: a public health threat on the wait (Publications)
BACKGROUND: Ambrosia artemisiifolia (short name = Ambrosia common ragweed) pollen is a potent allergen and has recently been found in Switzerland, spreading from the southwest of the country. The aim
Occupational exposure and risk of chronic obstructive pulmonary disease: a systematic review and meta-analysis (Publications)
INTRODUCTION: Due to contradictory literature we have performed a systematic review and meta-analyse of population-based studies that have used Job Exposure Matrices to assess occupational exposure an
Gender differences in adult-onset asthma: results from the Swiss SAPALDIA cohort study (Publications)
A higher incidence of asthma is reported in women compared with men, but evidence in later adulthood is limited. We aimed to determine the 20-year cumulative incidence of adult asthma in Switzerland a