Antitrypanosomal activity of some medicinal plants from Nigerian ethnomedicine (Publications)
Human African trypanosomiasis is a neglected tropical disease with complex clinical presentation, diagnosis, and difficult treatment. The available drugs for the treatment of trypanosomiasis are old,
Novel linear triaryl guanidines, N-substituted guanidines and potential prodrugs as antiprotozoal agents (Publications)
A series of triaryl guanidines and N-substituted guanidines designed to target the minor groove of DNA were synthesized and evaluated as antiprotozoal agents. Selected carbamate prodrugs of these guan
<em>In vitro</em> antileishmanial, antiplasmodial and cytotoxic activities of a new ventiloquinone and five known triterpenes from <em>Parinari... (Publications)
Context: Parinari excelsa Sabine (Chrysobalanaceae) is an indigenous tree from West and Eastern Africa. This tree is used in Ivory Coast as an antimalaria remedy. Objective: The in vitro antiplasmodia
Lysyl oxidase expression is an independent marker of prognosis and a predictor of lymph node metastasis in oral and oropharyngeal squamous cell... (Publications)
Proteins of the lysyl oxidase (LOX) family are important modulators of the extracellular matrix. However, they have an important role in the tumour development as well as in tumour progression. To eva
Design and synthesis of a series of melamine-based nitroheterocycles with activity against trypanosomatid parasites (Publications)
The parasites that give rise to human African trypanosomiasis (HAT) are auxotrophs for various nutrients from the human host, including purines. They have specialist nucleoside transporters to import
Synthesis and antiprotozoal activity of cationic 1,4-diphenyl-1<em>H</em>-1,2,3-triazoles (Publications)
Novel dicationic triazoles 1-60 were synthesized by the Pinner method from the corresponding dinitriles, prepared via the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The type and the place