Comparative analysis of <em>Mycobacterium tuberculosis</em> <em>pe </em>and <em>ppe</em> genes reveals high sequence variation and an apparent absence... (Publications)
Mycobacterium tuberculosis complex (MTBC) genomes contain 2 large gene families termed pe and ppe. The function of pe/ppe proteins remains enigmatic but studies suggest that they are secreted or cell
Development of an in vitro drug screening assay using <em>Schistosoma haematobium</em> schistosomula (Publications)
ABSTRACT: BACKGROUND: The development of novel antischistosomal drugs is crucial, as currently no vaccine and only a single drug is available for the treatment of schistosomiasis. Fast and accurate in
<em>Plasmodium falciparum</em> resistance to anti-malarial drugs in Papua New Guinea: evaluation of a community-based approach for the molecular... (Publications)
BACKGROUND: Molecular monitoring of parasite resistance has become an important complementary tool in establishing rational anti-malarial drug policies. Community surveys provide a representative samp
Genome-wide identification of molecular mimicry candidates in parasites (Publications)
Among the many strategies employed by parasites for immune evasion and host manipulation, one of the most fascinating is molecular mimicry. With genome sequences available for host and parasite, mimic
Safety and efficacy of the 10-day melarsoprol schedule for the treatment of second stage rhodesiense sleeping sickness (Publications)
OBJECTIVE: Assessment of the safety and efficacy of a 10-day melarsoprol schedule in second stage T.b. rhodesiense patients and the effect of suramin-pretreatment on the incidence of encephalopathic s
Mefloquine - an aminoalcohol with promising antischistosomal properties in mice (Publications)
BACKGROUND: The treatment and control of schistosomiasis, an often neglected tropical disease that exacerbates poverty, depends on a single drug, praziquantel. The large-scale use of praziquantel migh
Differential patterns of infection and disease with <em>P. falciparum</em> and <em>P. vivax</em> in young Papua New Guinean children (Publications)
BACKGROUND: Where P. vivax and P. falciparum occur in the same population, the peak burden of P. vivax infection and illness is often concentrated in younger age groups. Experiences from malaria thera