The effect of dose on the antimalarial efficacy of artemether-lumefantrine: a systematic review and pooled analysis of individual patient data (Publications)
BACKGROUND: Artemether-lumefantrine is the most widely used artemisinin-based combination therapy for malaria, although treatment failures occur in some regions. We investigated the effect of dosing s
Long-term exposure to particulate matter constituents and the incidence of coronary events in 11 European cohorts (Publications)
BACKGROUND: Long-term exposure to particulate matter (PM) has been associated with increased cardiovascular morbidity and mortality but little is known about the role of the chemical composition of PM
Using lung cancer mortality to indirectly approximate smoking patterns in space (Publications)
Smoking is the leading cause of lung cancer. Non-smoking factors have been associated with the disease. Existing Swiss survey data only capture the country partially and temporal coverage does not all
Prevalence and factors associated with convulsive status epilepticus in Africans with epilepsy (Publications)
OBJECTIVE: We conducted a community survey to estimate the prevalence and describe the features, risk factors, and consequences of convulsive status epilepticus (CSE) among people with active convulsi
No fever, no malaria? A diagnostic challenge in an immunocompromised patient (Publications)
We describe the case of an immunosuppressed women with proven malaria tropicana. Fever was not reported with this patient. We conclude that the concept of using fever as a primary surrogate indicator
Changing from whole-cell to acellular pertussis vaccines would trade superior tolerability for inferior protection (Publications)
Notifications of infant deaths, assumed to be related to the introduction of new pentavalent DTwP-Hib-HBV childhood vaccines, caused, during 2008-2010 in few Asian countries, temporary interruptions o
International scale implementation of the CNOSSOS-EU road traffic noise predictin model for epidemiological studies (Publications)
The EU-FP7-funded BioSHaRE project is using individual-level data pooled from several national cohort studies in Europe to investigate the relationship of road traffic noise and health. The detailed i
Spatial distribution of schistosomiasis and treatment needs in sub-Saharan Africa: a systematic review and geostatistical analysis (Publications)
BACKGROUND: Schistosomiasis affects more than 200 million individuals, mostly in sub-Saharan Africa, but empirical estimates of the disease burden in this region are unavailable. We used geostatistica
Gift from nature: cyclomarin a kills mycobacteria and malaria parasites by distinct modes of action (Publications)
Malaria continues to be one of the most devastating human diseases despite many efforts to limit its spread by prevention of infection or by pharmaceutical treatment of patients. We have conducted a s
Structure elucidation and activity of kolossin A, the D-/L-pentadecapeptide product of a giant nonribosomal peptide synthetase (Publications)
The largest continuous bacterial nonribosomal peptide synthetase discovered so far is described. It consists of 15 consecutive modules arising from an uninterrupted, fully functional gene in the entom