In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in <em>Plasmodium</em> models (Publications)
The objective of this work was to characterize the in vitro (Plasmodium falciparum) and in vivo (Plasmodium berghei) activity profile of the recently discovered lead compound SSJ-183. The molecule sho
Development of a glycoconjugate vaccine to prevent meningitis in Africa caused by meningococcal serogroup X (Publications)
Neisseria meningitidis is a major cause of bacterial meningitis worldwide, especially in the African meningitis belt, and has a high associated mortality. The meningococcal serogroups A, W, and X have
Air pollution and childhood leukaemia: a nationwide case-control study in Italy (Publications)
OBJECTIVES: Leukaemia is the most common cancer in children, but its aetiology is still poorly understood. We tested the hypothesis that traffic-related air pollution is associated with paediatric leu
Adenosinergic mechanisms contribute to individual differences in sleep deprivation-induced changes in neurobehavioral function and brain rhythmic... (Publications)
Large individual differences characterize the changes induced by sleep deprivation on neurobehavioral functions and rhythmic brain activity. To investigate adenosinergic mechanisms in these difference
<em>In vitro</em> metabolic profile and <em>in vivo</em> antischistosomal activity studies of (n6-praziquantel)Cr(Co)3 derivatives (Publications)
In vitro metabolic behavior was investigated for two chromium tricarbonyl derivatives of the antischistosomal drug praziquantel (PZQ) with the formula (?(6)-PZQ)Cr(CO)3 (1 and 2), by use of human live
Simple variables predict miserable outcome after intravenous thrombolysis (Publications)
BACKGROUND AND PURPOSE: To test the predictability of miserable outcome amongst ischaemic stroke patients receiving intravenous thrombolysis (IVT) based on a simple variables model (SVM) and to compar