Efficacy, safety and pharmacokinetics of 1,2,4-trioxolane OZ78 against an experimental infection with <em>Fasciola hepatica</em> in sheep (Publications)
The synthetic peroxide OZ78 is an effective flukicide in the rodent model, but the potential of OZ78 in target animals has not been studied to date. In the present study, OZ78 was administered at 50mg
Isothermal microcalorimetry to study the activity of triclabendazole and its metabolites on juvenile and adult <em>Fasciola hepatica</em> (Publications)
Isothermal microcalorimetry (IMC) is an analytical tool that continuously measures the heat flow generated by chemical, physical or biological processes. We have demonstrated that IMC is a useful tool
Association between <em>Schistosoma mansoni </em>and hookworm infections among schoolchildren in Côte d'Ivoire (Publications)
Infections with Schistosoma mansoni and hookworms are widespread in sub-Saharan Africa and the burden of disease associated with both parasites is enormous. Although there is a large overlap in their
Malaria elimination: moving forward with spatial decision support systems (Publications)
Operational challenges facing contemporary malaria elimination have distinct geospatial elements including the need for high-resolution location-based surveillance, targeted prevention and response in
<em>In vivo</em> activity of aryl ozonides against <em>Schistosoma</em> species (Publications)
We evaluated the in vivo antischistosomal activities of 11 structurally diverse synthetic peroxides. Of all compounds tested, ozonide (1,2,4-trioxolane) OZ418 had the highest activity against adult Sc