Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria (Publications)
Malaria remains one of the greatest public health challenges worldwide, particularly in sub-Saharan Africa. The clinical outcome of individuals infected with Plasmodium falciparum parasites depends on
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors (Publications)
Antimalarial drugs have thus far been chiefly derived from two sources-natural products and synthetic drug-like compounds. Here we investigate whether antimalarial agents with novel mechanisms of acti
<em>Plasmodium</em> gametocytes display homing and vascular transmigration in the host bone marrow (Publications)
Transmission of Plasmodium parasites to the mosquito requires the formation and development of gametocytes. Studies in infected humans have shown that only the most mature forms of Plasmodium falcipar
Morbidity associated with <em>Schistosoma mekongi </em>and concurrent helminth infection in Lao People's Democratic Republic (Publications)
In 2006, some 7 years after the halt of a multi-year schistosomiasis control programme, a study was conducted in the southern part of Lao People's Democratic Republic to determine the morbidity associ
Antimalarial <em>N</em>1,<em>N</em>3-dialkyldioxonaphthoimidazoliums: synthesis, biological activity, and structure-activity relationships (Publications)
Here we report the nanomolar potencies of N (1),N (3)-dialkyldioxonaphthoimidazoliums against asexual forms of sensitive and resistant Plasmodium falciparum. Activity was dependent on the presence of
Leprosy post-exposure prophylaxis with single-dose rifampicin: toolkit for implementation (Publications)
lNLR, Amsterdam, NetherlandsmPrivate, UKnHealth Services, Dadra and Nagar Haveli, IndiaoNLR, Jakarta, IndonesiapAnti-Leprosy Campaign, Colombo, Sri LankaqUniversidade do Estado de Mato Grosso, Ca ́cer
Correlates and outcomes of low physical activity posttransplant: a systematic review and meta-analysis (Publications)
BACKGROUND: Little is known about associations between low physical activity (PA) and its correlates and outcomes in solid organ transplant recipients. This systematic review with meta-analysis examin
High genomic diversity and heterogenous origins of pathogenic and antibiotic-resistan<em>t Escherichia coli </em>in household settings represent a... (Publications)
Escherichia coli is present in multiple hosts and environmental compartments as a normal inhabitant, temporary or persistent colonizer, and as a pathogen. Transmission of E. coli between hosts and wit
Gambiense human African trypanosomiasis sequelae after treatment: a follow-up study 12 years after treatment (Publications)
The clinical presentation of Human African Trypanosomiasis (HAT) due to Trypanosoma brucei gambiense is well known, but knowledge on long-term sequelae is limited. In the frame of studies conducted be