<em>In vitro</em> antileishmanial and antischistosomal activities of anemonin isolated from the fresh leaves of <em>Ranunculus multifidus</em> forsk (Publications)
Leishmaniasis and schistosomiasis are neglected tropical diseases (NTDs) infecting the world's poorest populations. Effectiveness of the current antileishmanial and antischistosomal therapies are sign
Spatial and temporal variations in PM10 concentrations between 2010-2017 in South Africa (Publications)
Particulate matter less than or equal to 10 mum in aerodynamic diameter (PM10 microg/m(3)) is a priority air pollutant and one of the most widely monitored ambient air pollutants in South Africa. This
Ambient air pollution and cardiorespiratory outcomes amongst adults residing in four informal settlements in the western province of South Africa (Publications)
Few studies have investigated the relationship between ambient air pollution and cardiorespiratory outcomes in Africa. A cross-sectional study comprising of 572 adults from four informal settlements i
Accuracy of an amplicon-sequencing nanopore approach to identify variants in tuberculosis drug-resistance-associated genes (Publications)
A rapid and accurate diagnostic assay represents an important means to detect Mycobacterium tuberculosis, identify drug-resistant strains and ensure treatment success. Currently employed techniques to
Extracellular matrix-induced GM-CSF and hypoxia promote immune control of<em> Mycobacterium tuberculosis </em>in human <em>in vitro</em> granulomas (Publications)
Several in vitro cellular models have been developed with the aim to reproduce and dissect human granulomatous responses, the hallmark of tuberculosis (TB) immunopathogenesis. In that context, we comp
Early life adversity, biological adaptation, and human capital: evidence from an interrupted malaria control program in Zambia (Publications)
Growing evidence from evolutionary biology demonstrates how early life shocks trigger physiological changes designed to be adaptive in challenging environments. We examine the implications of one type
Risk profiling and efficacy of albendazole against the hookworms<em> Necator americanus </em>and <em>Ancylostoma ceylanicum</em> in Cambodia to... (Publications)
Background: Hookworm disease is endemic throughout many parts of the Asia Pacific, despite targeted control programs of at-risk populations. The success of these programs has been hindered by the limi
Nonrandom selection and multiple blood feeding of human hosts by <em>Anopheles </em>vectors: implications for malaria transmission in Papua New Guinea (Publications)
Nonrandom selection and multiple blood feeding of human hosts by Anopheles mosquitoes may exacerbate malaria transmission. Both patterns of blood feeding and their relationship to malaria epidemiology
Hygroline derivatives from <em>Schizanthus tricolor </em>and their anti-trypanosomatid and antiplasmodial activities (Publications)
Chemical investigation of the alkaloid extract of the aerial parts of Schizanthus tricolor led to the targeted isolation of 26 hygroline derivatives of which 20 were fully characterized. They have not
Preventing leprosy with retrospective active case finding combined with single-dose rifampicin for contacts in a low endemic setting: results of the... (Publications)
Post-exposure prophylaxis (PEP) with single-dose rifampicin (SDR) reduces the risk of developing leprosy among contacts of leprosy patients. Most evidence for the feasibility of the intervention is fr