Assembling a global database of child pneumonia studies to inform WHO pneumonia management algorithm: methodology and applications (Publications)
BACKGROUND: The existing World Health Organization (WHO) pneumonia case management guidelines rely on clinical symptoms and signs for identifying, classifying, and treating pneumonia in children up to
Comparison of model predictions of typhoid conjugate vaccine public health impact and cost-effectiveness (Publications)
Models are useful to inform policy decisions on typhoid conjugate vaccine (TCV) deployment in endemic settings. However, methodological choices can influence model-predicted outcomes. To provide robus
Household-level risk factors for water contamination and antimicrobial resistance in drinking water among households with children under 5 in rural... (Publications)
Household water contamination at point of use depends on human, animal and environmental factors embodying all aspects of a One Health approach. This study investigated the association between househo
Limited efficacy of repeated praziquantel treatment in <em>Schistosoma mansoni</em> infections as revealed by highly accurate diagnostics, PCR and... (Publications)
BACKGROUND: Most studies assessing praziquantel (PZQ) efficacy have used relatively insensitive diagnostic methods, thereby overestimating cure rate (CR) and intensity reduction rate (IRR). To determi
Helminth infections: enabling the World Health Organization road map (Publications)
Helminthiases are considered among the most persistent public health problems. Control and/or elimination remains a global health challenge and the World Health Organization Road Map highlights critic
Severe acute respiratory coronavirus virus 2 (SARS-CoV-2) seroprevalence in healthcare personnel in northern California early in the coronavirus... (Publications)
OBJECTIVE: We assessed the magnitude of unidentified coronavirus disease 2019 (COVID-19) in our healthcare personnel (HCP) early in the COVID-19 pandemic, and we evaluated risk factors for infection t
Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome (Publications)
SARS-CoV-2-specific antibodies, particularly those preventing viral spike receptor binding domain (RBD) interaction with host angiotensin-converting enzyme 2 (ACE2) receptor, can neutralize the virus.
Large-scale testing of asymptomatic healthcare personnel for severe acute respiratory syndrome coronavirus 2 (Publications)
Large-scale, 1-time testing of > 12,000 asymptomatic healthcare personnel in California, USA, during April-June 2020 showed that prevalence of severe acute respiratory syndrome coronavirus 2 was low (
Modeling human adaptive immune responses with tonsil organoids (Publications)
Most of what we know about adaptive immunity has come from inbred mouse studies, using methods that are often difficult or impossible to confirm in humans. In addition, vaccine responses in mice are o