Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria (Publications)
The antiplasmodial activity of a series of spirotetrahydro beta-carbolines is described. Racemic spiroazepineindole (1) was identified from a phenotypic screen on wild type Plasmodium falciparum with
Monitoring chloroquine resistance using <em>Plasmodium falciparum</em> parasites isolated from wild mosquitoes in Tanzania (Publications)
Monitoring antimalarial drug resistance is a useful epidemiologic tool and provides early detection of resistance foci. Using DNA extracted from the head/thorax of wild mosquitoes collected from Bagam
The procyclin-associated genes of <em>Trypanosoma brucei</em> are not essential for cyclical transmission by tsetse (Publications)
EP and GPEET procyclins are the major surface glycoproteins of Trypanosoma brucei in the midgut of tsetse flies (Glossina spp.). The procyclin genes are located at the beginning of polycistronic trans
A Mitogen-activated protein kinase controls differentiation of bloodstream forms of <em>Trypanosoma brucei</em> (Publications)
African trypanosomes undergo differentiation in order to adapt to the mammalian host and the tsetse fly vector. To characterize the role of a mitogen-activated protein (MAP) kinase homologue, TbMAPK5,