Methotrexate and aminopterin lack in vivo antimalarial activity against murine malaria species (Publications)
The antifolate anticancer drug methotrexate (MTX) has potent activity against Plasmodium falciparum in vitro. Experience of its use in the treatment of rheumatoid arthritis indicates that it could be
Exploring prospects of novel drugs for tuberculosis (Publications)
Tuberculosis remains a disease with an enormous impact on public health worldwide. With the continuously increasing epidemic of drug-resistant tuberculosis, new drugs are desperately needed. However,
Antitrypanosomal sesquiterpene lactones from <em>Saussurea costus</em> (Publications)
In the course of a larger screen of 1800 plant and fungal extracts, the ethyl acetate extract of Saussurea costus roots potently inhibited the growth of Trypanosoma brucei rhodesiense. Subsequent HPLC
Selection bias of elderly patients with chronic angina referred for catheterization (Publications)
BACKGROUND: Registry patients are generally older and more sick than patients enrolled in trials questioning the generalizability of trial results. We assessed whether such a selection bias also exist
Analogues of thiolactomycin as potential antimalarial agents (Publications)
Analogues of the natural antibiotic thiolactomycin (TLM), an inhibitor of the condensing reactions of type II fatty acid synthase, were synthesized and evaluated for their ability to inhibit the growt
Spousal violence in Bangladesh: a call for a public-health response (Publications)
Spousal violence against women is a serious public-health issue. Although there is a growing body of literature on this subject, there are still many unanswered questions regarding the prevalence of t
Longitudinal assessment of <em>Plasmodium falciparum v</em>ar gene transcription in naturally infected asymptomatic children in Papua New Guinea (Publications)
Sequestration and antigenic variation are essential for Plasmodium falciparum survival in vivo contributing to severe pathologic findings and, also, chronic infection. Both are conferred by P. falcipa