Potential long-term toxicity of repeated orally administered doses of artemether in rats (Publications)
Artemether, an efficacious antimalarial drug, effectively prevents patent schistosome infections and morbidity, as established in laboratory models and in clinical trials. In view of concern about the
Novel <em>Bacteroides</em> host strains for detection of human- and animal-specific bacteriophages in water (Publications)
Bacteriophages active against specific Bacteroides host strains were shown to be suitable for detection of human faecal pollution. However, the practical application of this finding is limited because
Identification of fecal input sites in spring water by selection and genotyping of multiresistant <em>Escherichia coli</em> (Publications)
The localization of fecal input sites is important for water quality management. For this purpose, we have developed a new approach based on a three-step procedure, including a preparatory phase, the
Assessing health impacts in complex eco-epidemiological settings in the humid tropics: advancing tools and methods (Publications)
In the developing world. large-scale projects in the extractive industry and natural resources sectors are often controversial and associated with long-term adverse health consequences to local commun
Effect of single-dose oral artemether and tribendimidine on the tegument of adult <em>Clonorchis sinensis</em> in rats (Publications)
The tegument of trematodes plays a key role in nutrient absorption, exerts secretory functions, protects the parasite against the immune system of the host, and is a target for anti-trematocidal drugs
dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors (Publications)
Pyrimidine metabolism is a major route for therapeutic intervention against malaria. Here we report inhibition and structural studies on the deoxyuridine nucleotidohydrolase from the malaria parasite
Artemether, artesunate, praziquantel and tribendimidine administered singly at different dosages against <em>Clonorchis sinensis</em>: acomparative in... (Publications)
We comparatively assessed the in vivo efficacy of artemether, artesunate, praziquantel and tribendimidine against different stages of Clonorchis sinensis. Rats were infected with 40-50 C. sinensis met
Ultrastructural alterations in adult <em>Schistosoma mansoni</em> caused by artemether (Publications)
Progress has been made over the last decade with the development and clinical use of artemether as an agent against major human schistosome parasites. The tegument has been identified as a key target