Circulating alpha1-antitrypsin in the general population: determinants and association with lung function (Publications)
BACKGROUND: Severe alpha1-antitrypsin (AAT) deficiency associated with low AAT blood concentrations is an established genetic COPD risk factor. Less is known about the respiratory health impact of var
Determinants of change in airway reactivity over 11 years in a population study (SAPALDIA) (Publications)
We investigated determinants of change in bronchial reactivity in SAPALDIA, a population-based cohort with wide age range (29-72 years at follow-up). The role of sex, age, atopic status, smoking and B
<em>SERPINA1</em> PiZ and PiS heterozygotes and lung function decline in the SAPALDIA cohort (Publications)
BACKGROUND: Severe alpha1-antitrypsin (AAT) deficiency is a strong risk factor for COPD. But the impact of gene variants resulting in mild or intermediate AAT deficiency on the longitudinal course of
Mortality along the continuum of HIV care in Rwanda: a model-based analysis (Publications)
BACKGROUND: HIV is the leading cause of death among adults in sub-Saharan Africa. However, mortality along the HIV care continuum is poorly described. We combine demographic, epidemiologic, and health
Excretory/secretory products from the gastrointestinal nematode <em>Trichuris muris</em> (Publications)
To better control gastrointestinal nematode infections in humans and animals, it is important to understand the strategies used by these parasites to modulate the host immune system. In this regard, m
Whole genome sequencing distinguishes between relapse and reinfection in recurrent leprosy cases (Publications)
BACKGROUND: Since leprosy is both treated and controlled by multidrug therapy (MDT) it is important to monitor recurrent cases for drug resistance and to distinguish between relapse and reinfection as
Effects of long-term exposure to air pollution on natural-cause mortality: an analysis of 22 European cohorts within the multicentre ESCAPE project (Publications)
BACKGROUND: Few studies on long-term exposure to air pollution and mortality have been reported from Europe. Within the multicentre European Study of Cohorts for Air Pollution Effects (ESCAPE), we aim
Environmental tobacco smoke exposure and diabetes in adult never-smokers (Publications)
BACKGROUND: Active smoking has been linked to type 2 diabetes mellitus (T2DM) but only few recent studies have shown environmental tobacco smoke (ETS) to be associated with DM in never-smokers. We ass
Hypertension, diabetes and lifestyle in the long-term - results from a Swiss population-based cohort (Publications)
Healthy lifestyles are integral in preventing and treating common cardiovascular and metabolic diseases. The aim of this study was to observe smoking habits, alcohol intake, physical activity and body