Association between advanced glycation end products and impaired fasting glucose: results from the SALIA study (Publications)
Advanced glycation end products (AGEs) may contribute to the development of type 2 diabetes and related complications, whereas their role in the early deterioration of glycaemia is unknown. While prev
Repurposing of anticancer drugs: <em>in vitro</em> and<em> in vivo</em> activities against <em>Schistosoma mansoni</em> (Publications)
BACKGROUND: Drug discovery for the neglected tropical disease schistosomiasis has a high priority. Anticancer drugs, especially protein kinase inhibitors, might serve as a starting point for drug disc
Targeting the parasite's DNA with methyltriazenyl purine analogs is a safe, selective and efficacious antitrypanosomal strategy (Publications)
The human and veterinary disease complex known as African trypanosomiasis continues to inflict significant global morbidity, mortality and economic hardship. Drug resistance and toxic side effects of
Malaria eradication and elimination: views on how to translate a vision into reality (Publications)
Although global efforts in the past decade have halved the number of deaths due to malaria, there are still an estimated 219 million cases of malaria a year, causing more than half a million deaths. I
AMBITION-cm: intermittent high dose AmBisome on a high dose fluconazole backbone for cryptococcal meningitis induction therapy in sub-Saharan Africa:... (Publications)
BACKGROUND: Cryptococcal meningitis (CM) is a leading cause of mortality among HIV-infected individuals in Africa. Poor outcomes from conventional antifungal therapies, unavailability of flucytosine,
The integrated disease surveillance and response system in northern Ghana: challenges to the core and support functions (Publications)
BACKGROUND: The integrated disease surveillance and response (IDSR) strategy was adopted in Ghana over a decade ago, yet gaps still remain in its proper functioning. The objective of this study was to
Incidence, remission and mortality of convulsive epilepsy in rural Northeast South Africa (Publications)
BACKGROUND: Epilepsy is one of the most common neurological conditions globally, estimated to constitute 0.75% of the global burden of disease, with the majority of this burden found in low- and middl