<em>In vitro</em> and <em>in vivo</em> efficacy of Monepantel (AAD 1566) against laboratory models of human intestinal nematode infections (Publications)
BACKGROUND: Few effective drugs are available for soil-transmitted helminthiases and drug resistance is of concern. In the present work, we tested the efficacy of the veterinary drug monepantel, a pot
A research agenda for malaria eradication: diagnoses and diagnostics (Publications)
Many of malaria's signs and symptoms are indistinguishable from those of other febrile diseases. Detection of the presence of Plasmodium parasites is essential, therefore, to guide case management. Im
Design and pre-clinical profiling of a <em>Plasmodium falciparum</em> MSP-3 derived component for a multi-valent virosomal malaria vaccine (Publications)
BACKGROUND: Clinical profiling of two components for a synthetic peptide-based virosomal malaria vaccine has yielded promising results, encouraging the search for additional components for inclusion i
Studies on the mechanisms supporting the continuous growth of <em>Trypanosoma (Trypanozoon) brucei</em> as bloodstream-like form in vitro (Publications)
The conditions which enable growth of Trypanosoma (T.) brucei stock S 427 as bloodstream-like form over bovine fibroblast-like cells (BHF) were analyzed. The experiments with different BHF conditioned
FlexiChip package: an universal microarray with a dedicated analysis software for high-thoughput SNPs detection linked to anti-malarial drug... (Publications)
BACKGROUND: A number of molecular tools have been developed to monitor the emergence and spread of anti-malarial drug resistance to Plasmodium falciparum. One of the major obstacles to the wider imple
<em>Dipetalonema viteae</em> (Filarioidea): development of the infective larvae in vitro (Publications)
The development of Dipetalonema viteae third stage larvae was attempted in vitro. A monophasic culture system consisting of BHK-21 medium supplemented with 10% tryptose-phosphate broth and 15% fresh j
Estimation of heterogeneity in malaria transmission by stochastic modelling of apparent deviations from mass action kinetics (Publications)
BACKGROUND: Quantifying heterogeneity in malaria transmission is a prerequisite for accurate predictive mathematical models, but the variance in field measurements of exposure overestimates true micro