Spiro- and dispiro-1,2-dioxolanes: contribution of iron(II)-mediated one-electron vs two-electron reduction to the activity of antimalarial peroxides (Publications)
Fourteen spiro- and dispiro-1,2-dioxolanes were synthesized by peroxycarbenium ion annulations with alkenes in yields ranging from 30% to 94%. Peroxycarbenium ion precursors included triethylsilyldipe
Comparative antiplasmodial, leishmanicidal and antitrypanosomal activities of several biflavonoids (Publications)
The antiplasmodial, leishmanicidal and antitrypanosomal activities of eight natural biflavonoids were estimated in vitro on a chloroquine-resistant strain of Plasmodium falciparum, axenically grown Le
Demographic and health surveillance of mobile pastoralists in Chad: integration of biometric fingerprint identification into a geographical... (Publications)
There is a pressing need for baseline demographic and health-related data to plan, implement and evaluate health interventions in developing countries, and to monitor progress towards international de
Visceral leishmaniasis: a threat to immunocompromised patients in non-endemic areas? (Publications)
Visceral leishmaniasis is rare in western Europe, but may be life-threatening in immunocompromised patients. It is therefore important to understand the incidence of the disease in a non-endemic area
Cyclic nucleotide-specific phosphodiesterases of <em>Plasmodium falciparum</em>: PfPDEalpha, a non-essential cGMP-specific PDE that is an integral... (Publications)
Cyclic nucleotide-specific phosphodiesterases (PDEs) have come into focus as interesting potential targets for PDE inhibitor-based anti-parasitic drugs. Genomes of the various agents of human malaria,
New treatment option for second stage African sleeping sickness: In vitro and in vivo efficacy of aza analogs of DB289 (Publications)
African sleeping sickness is a fatal parasitic disease and all drugs currently in use for treatment have strong liabilities. It is essential to find new, effective and less toxic drugs ideally with or
Inverse association of farm milk consumption with asthma and allergy in rural and suburban populations across Europe (Publications)
Background Dietary interventions as a means for atopy prevention attract great interest. Some studies in rural environments claimed an inverse association between consumption of farmproduced dairy pro