Effect of single-dose oral artemether and tribendimidine on the tegument of adult <em>Clonorchis sinensis</em> in rats (Publications)
The tegument of trematodes plays a key role in nutrient absorption, exerts secretory functions, protects the parasite against the immune system of the host, and is a target for anti-trematocidal drugs
dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors (Publications)
Pyrimidine metabolism is a major route for therapeutic intervention against malaria. Here we report inhibition and structural studies on the deoxyuridine nucleotidohydrolase from the malaria parasite
Artemether, artesunate, praziquantel and tribendimidine administered singly at different dosages against <em>Clonorchis sinensis</em>: acomparative in... (Publications)
We comparatively assessed the in vivo efficacy of artemether, artesunate, praziquantel and tribendimidine against different stages of Clonorchis sinensis. Rats were infected with 40-50 C. sinensis met
Ultrastructural alterations in adult <em>Schistosoma mansoni</em> caused by artemether (Publications)
Progress has been made over the last decade with the development and clinical use of artemether as an agent against major human schistosome parasites. The tegument has been identified as a key target
Transmission electron microscopic observations on ultrastructural damage in juvenile <em>Schistosoma mansoni</em> caused by artemether (Publications)
Artemether, a derivative of the antimalarial artemisinin, has been shown to induce rapid and extensive alteration to the tegument of juvenile Schistosoma japonicum, S. mansoni and S. haematobium. Less
Spatial-temporal and cancer risk assessment of selected hazardous air pollutants in Seattle (Publications)
In the Seattle Air Toxics Monitoring Pilot Program, we measured 15 hazardous air pollutants (HAPs) at 6 sites for more than a year between 2000 and 2002. Spatial-temporal variations were evaluated wit