Structure–activity relationship and<em> in vitro</em> absorption, distribution, metabolism, excretion, and toxicity (ADMET) studies of <em>N</em>-aryl... (Publications)
We have previously reported on the antischistosomal activity of pyrido [1,2-a] benzimidazole (PBI) derivatives. As a follow-up, we designed and prosecuted further structure-activity relationship (SAR)
Discovery and characterization of <em>Mycobacterium basiliense</em> sp. nov., a nontuberculous <em>Mycobacterium </em>isolated from human lungs (Publications)
Bacteria belonging to the genus Mycobacterium are predominantly responsible for pulmonary diseases; most notably Mycobacterium tuberculosis causes granulomatous pulmonary infections. Here we describe
Current use and costs of electronic health records for clinical trial research: a descriptive study (Publications)
BACKGROUND: Electronic health records (EHRs) may support randomized controlled trials (RCTs). We aimed to describe the current use and costs of EHRs in RCTs, with a focus on recruitment and outcome as
Diagnoses made in an emergency department in rural sub-Saharan Africa (Publications)
BACKGROUND: Information on diagnoses made in emergency departments situated in rural sub-Saharan Africa is scarce. The aim was: to evaluate the frequency of different diagnoses made in a new emergency
Association of long-term exposure to traffic-related PM10 with heart rate variability and heart rate dynamics in healthy subjects (Publications)
BACKGROUND: Epidemiological evidence on the influence of long-term exposure to traffic-related particulate matter (TPM10) on heart rate variability (HRV) is weak. OBJECTIVE: To evaluate the associatio
Potential factors influencing lymphatic filariasis transmission in “hotspot” and “control” areas in Ghana: the importance of vectors (Publications)
BACKGROUND: Mass drug administration (MDA) programmes for the control of lymphatic filariasis in Ghana, have been ongoing in some endemic districts for 16 years. The current study aimed to assess fact
Safety and efficacy of C-reactive protein-guided antibiotic use to treat acute respiratory infections in Tanzanian children: a planned subgroup... (Publications)
Background: Antibiotic overuse in pediatric primary care in resource-limited settings is driven by respiratory infections. The safety and efficacy of using C-reactive protein (CRP) to decide on antibi
Flood governance for resilience in cities: the historical policy transformations in Dakar's suburbs (Publications)
Flooding disasters in urban and suburban Dakar have been prioritised in various policy actions over the last two decades. Our research aimed to generate a historical overview of the progressive transf
Risk factors for detection, survival, and growth of antibiotic-resistant and pathogenic <em>Escherichia coli </em>in household soils in rural... (Publications)
Soils in household environments in low- and middle-income countries may play an important role in the persistence, proliferation, and transmission of Escherichia coli Our goal was to investigate the r
Optimization of novel 1-methyl-1 h-pyrazole-5-carboxamides leads to high potency larval development inhibitors of the barber's pole worm (Publications)
A phenotypic screen of a diverse library of small molecules for inhibition of the development of larvae of the parasitic nematode Haemonchus contortus led to the identification of a 1-methyl-1 H-pyraz