Intravenous artesunate reduces parasite clearance time, duration of intensive care and hospital treatment in patients with severe malaria in Europe:... (Publications)
Intravenous artesunate improves survival in severe malaria, but clinical trial data from non-endemic countries are scarce. The TropNet severe malaria database was analyzed to compare outcomes of artes
Co-option of membrane wounding enables virus penetration into cells (Publications)
During cell entry, non-enveloped viruses undergo partial uncoating to expose membrane lytic proteins for gaining access to the cytoplasm. We report that adenovirus uses membrane piercing to induce and
DNA replication fidelity in <em>Mycobacterium tuberculosis</em> is mediated by an ancestral prokaryotic proofreader (Publications)
The DNA replication machinery is an important target for antibiotic development in increasingly drug-resistant bacteria, including Mycobacterium tuberculosis. Although blocking DNA replication leads t
MMP-1 and -3 promoter variants are indicative of a common susceptibility for skin and lung aging: results from a cohort of elderly women (SALIA) (Publications)
Studies have indicated that there may be a smoking-dependent association between skin wrinkling and airflow obstruction of the lung. It was suggested that this association might be because of an under
6-Arylpyrazine-2-carboxamides: a new core for <em>Trypanosoma brucei</em> inhibitors (Publications)
From a whole-organism high throughput screen of approximately 87,000 compounds against Trypanosoma brucei brucei, we recently identified eight new unique compounds for the treatment of human African t
Predominance of <em>dfrG</em> as determinant of trimethoprim resistance in imported <em>Staphylococcus aureus</em> (Publications)
To investigate the global occurrence of trimethoprim-sulfamethoxazole resistance and the genetic mechanisms of trimethoprim resistance, we analysed Staphylococcus aureus from travel-associated skin an
Still far from 90-90-90: virologic outcomes of children on antiretroviral therapy in nurse-led clinics in rural Lesotho (Publications)
This survey assessed virologic outcomes of children on antiretroviral therapy and potential predictors in 10 nurse-led clinics in Lesotho. Success was achieved in 72% of the 191 children. No predictor