Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a softfocus kinase library: part 2 (Publications)
On the basis of our recent results on a novel series of imidazopyridazine-based antimalarials, we focused on identifying compounds with improved aqueous solubility and hERG profile while maintaining m
The determination of the species specificity of Leishmania antibodies in different groups of human sera (Publications)
Species-specificity of two serological tests has been compared: Indirect immunofluorescence test and C-ELISA using antigens prepared of 7 Leishmania species of various groups of human sera, including
Antigenicity and immunogenicity of a novel <em>Plasmodium vivax</em> circumsporozoite derived synthetic vaccine construct (Publications)
BACKGROUND: The circumsporozoite (CS) protein is a major malaria sporozoite surface antigen currently being considered as vaccine candidate. Plasmodium vivax CS (PvCS) protein comprises a dimorphic ce
Associations between air pollution and socioeconomic characteristics, ethnicity and age profile of neighbourhoods in England and the Netherlands (Publications)
Air pollution levels are generally believed to be higher in deprived areas but associations are complex especially between sensitive population subgroups. We explore air pollution inequalities at nati