Metabolic characterization of <em>Leishmania major</em> infection in activated and nonactivated macrophages (Publications)
Infection with Leishmania spp. can lead to a range of symptoms in the affected individual, depending on underlying immune-metabolic processes. The macrophage activation state hereby plays a key role.
Metabolic, immune, and gut microbial signals mount a systems response to <em>Leishmania major</em> infection (Publications)
Parasitic infections such as leishmaniasis induce a cascade of host physiological responses, including metabolic and immunological changes. Infection with Leishmania major parasites causes cutaneous l
Effect of ambient air pollution on hospital admission for respiratory diseases in Hanoi children during 2007-2019 (Publications)
Air pollution poses a threat to children's respiratory health. This study aims to quantify the association between short-term air pollution exposure and respiratory hospital admissions among children
Distribution and treatment needs of soil-transmitted helminthiasis in Bangladesh: a Bayesian geostatistical analysis of 2017-2020 national survey data (Publications)
BACKGROUND: In Bangladesh, preventive chemotherapy targeting soil-transmitted helminth (STH) infections in school-age children has been implemented since 2008. To evaluate the success of this strategy
Evidence synthesis of observational studies in environmental health: lessons learned from a systematic review on traffic-related air pollution (Publications)
BACKGROUND: There is a long tradition in environmental health of using frameworks for evidence synthesis, such as those of the U.S. Environmental Protection Agency for its Integrated Science Assessmen
Discovery of an orally active nitrothiophene-based antitrypanosomal agent (Publications)
Human African Trypanosomiasis (HAT), caused by Trypanosoma brucei gambiense and rhodesiense, is a parasitic disease endemic to sub-Saharan Africa. Untreated cases of HAT can be severely debilitating a
Recurrent abdominal wall mass in a hepatitis B-positive male: an unusual case of lumbar mycetoma (Publications)
KEY CLINICAL MESSAGE: Atypical presentations of eumycetoma can pose a challenge in the diagnosis and treatment of the disease. Healthcare providers thorough in their differential diagnosis and investi
Maternal stimulation and early child development in sub-Saharan Africa: evidence from Kenya and Zambia (Publications)
BACKGROUND: Despite major improvements in child survival over the past decade, many children in low and middle-income countries (LMICs) remain at risk of not reaching their developmental potential due
Can participatory processes lead to changes in the configuration of local mental health networks? a social network analysis (Publications)
Systems modeling offers a valuable tool to support strategic decision-making for complex problems because it considers the causal inter-relationships that drive population health outcomes. This tool c