Integrative pathway genomics of lung function and airflow obstruction (Publications)
Chronic respiratory disorders are important contributors to the global burden of disease. Genome-wide association studies (GWASs) of lung function measures have identified several trait-associated loc
Santé sexuelle: variabilités en Suisse et en Europe (Publications)
Sexual Health is interrelated with both, sex and gender, through its biological dimension, its connection with cultural conventions, and its impact on women's health. Reproductive factors are presente
Serum bilirubin is associated with lung function in a Swiss general population sample (Publications)
Bilirubin is a strong antioxidant. Increased serum levels were associated with respiratory disease and mortality risk. We studied the association of bilirubin with lung function in the SAPALDIA cohort
1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function (Publications)
HapMap imputed genome-wide association studies (GWAS) have revealed > 50 loci at which common variants with minor allele frequency > 5% are associated with kidney function. GWAS using more complete re
Systematic review of lung function and COPD with peripheral blood DNA methylation in population based studies (Publications)
BACKGROUND: Epigenetic variations in peripheral blood have potential as biomarkers for disease. This systematic review assesses the association of lung function and chronic obstructive pulmonary disea
Infectious diseases are associated with carotid intima media thickness in adolescence (Publications)
OBJECTIVE: Inflammatory risk factors in childhood, e.g. obesity, impact on carotid artery intima media thickness (CIMT), an early indicator of atherosclerosis. Little is known on potential infectious
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets (Publications)
Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function and is the third leading cause of death globally. Through genome-wide association discovery in 48,943 individuals
Land use regression models for ultrafine particles in six European areas (Publications)
Long-term ultrafine particle (UFP) exposure estimates at a fine spatial scale are needed for epidemiological studies. Land use regression (LUR) models were developed and evaluated for six European are
Ambient air pollution and adult asthma incidence in six European cohorts (ESCAPE) (Publications)
BACKGROUND: Short-term exposure to air pollution has adverse effects among patients with asthma, but whether long-term exposure to air pollution is a cause of adult-onset asthma is unclear. OBJECTIVE: