TNF-α–induced protein 3 is a key player in childhood asthma development and environment-mediated protection (Publications)
BACKGROUND: Childhood asthma prevalence is significantly higher in urban areas compared to rural/farm environments. Murine studies have shown that TNFAIP3 (TNF-alpha-induced protein 3, A20), an anti-i
Models of effectiveness of interventions against malaria transmitted by <em>Anopheles albimanus</em> (Publications)
BACKGROUND: Most impact prediction of malaria vector control interventions has been based on African vectors. Anopheles albimanus, the main vector in Central America and the Caribbean, has higher intr
Diagnostic performance of a single and duplicate Kato-Katz, Mini-FLOTAC, FECPAKG2 and qPCR for the detection and quantification of soil-transmitted... (Publications)
BACKGROUND: Because the success of deworming programs targeting soil-transmitted helminths (STHs) is evaluated through the periodically assessment of prevalence and infection intensities, the use of t
Ambient particulate air pollution and daily mortality in 652 cities (Publications)
BACKGROUND: The systematic evaluation of the results of time-series studies of air pollution is challenged by differences in model specification and publication bias. METHODS: We evaluated the associa
The HOSENG trial - effect of the provision of oral self-testing for absent and refusing individuals during a door-to-door HIV-testing campaign on... (Publications)
BACKGROUND: HIV-testing coverage remains below the targeted 90% despite efforts and resources invested. Home-based HIV-testing is a key approach endorsed by the World Health Organization (WHO), especi
Impact of the warm summer 2015 on emergency hospital admissions in Switzerland (Publications)
BACKGROUND: Only a few studies have examined the impact of a particular heat event on morbidity. The aim of this study was to evaluate the impact of the warm summer 2015 on emergency hospital admissio
Mechanistic dose-response modelling of animal challenge data shows that intact skin is a crucial barrier to leptospiral infection (Publications)
Leptospirosis is a widespread and potentially life-threatening zoonotic disease caused by spirochaetes of the genus Leptospira. Humans become infected primarily via contact with environmental reservoi
Targeting a large active site: structure-based design of nanomolar inhibitors of <em>Trypanosoma brucei </em>trypanothione reductase (Publications)
Trypanothione reductase (TR) plays a key role in the unique redox metabolism of trypanosomatids, the causative agents of human African trypanosomiasis (HAT), Chagas' disease, and leishmaniases. Introd