Medicines Development | Research at Swiss TPH (Page)
https://www.swisstph.ch/de/about/med/medicines-development
platforms, malaria drug resistance genotyping services and the development of vaccines and treatments for tropical infectious diseases. The MDU excels in providing global genotyping services for malaria resistance [...] on diseases such as malaria, respiratory viruses, Buruli ulcer and undifferentiated febrile diseases. Our Core Competencies Our core expertise is in molecular genotyping for malaria drug resistance testing [...] testing, diagnostic development of non-invasive and innovative...
Statistics in Epidemiology Group | Biostatistics at Swiss TPH (Page)
https://www.swisstph.ch/de/about/eph/biostatistics/statistics-in-epidemiology
analysis of cohorts, and in applications in non-communicable disease and infectious diseases such as malaria. The group runs statistics courses in the Faculty of Science and contributes to postgraduate courses [...] Maximise Universal Access Long-lasting insecticidal nets (LLINs), or bed nets, are the mainstay of malaria control. However, more than 50% of people living in endemic areas are currently unprotected because [...] lifespan. The goal of the ViALLIN MUsAcc project is to develop a...
Fredros Okumu Awarded Prestigious Research Prize (News)
https://www.swisstph.ch/de/news/news-detail-1/news/fredros-okumu-awarded-prestigious-research-prize
partners world-wide. Eliminating malaria-transmitting mosquitoes in Tanzania Okumu’s research focuses on developing species-specific methods of eliminating the malaria-transmitting mosquito Anopheles funestus [...] not the most populous mosquito species in the region, it is responsible for 82% to 95% of local malaria infections. IHI is not only a long-standing partner of Swiss TPH; Okumu himself is currently completing
Effect of large-scale social marketing of insecticide-treated nets on child survival in rural Tanzania (Publications)
BACKGROUND: Insecticide-treated nets have proven efficacy as a malaria-control tool in Africa. However, the transition from efficacy to effectiveness cannot be taken for granted. We assessed coverage and [...] programme for insecticide-treated nets in two rural districts of southern Tanzania with high perennial malaria transmission. METHODS: Socially marketed insecticide-treated nets were introduced step-wise over [...] INTERPRETATION: Social marketing of insecticide-treated nets has great...
Surveillance of molecular markers of <em>Plasmodium falciparum</em> artemisinin resistance (<em>kelch</em>13 mutations) in Papua New Guinea between... (Publications)
Plasmodium falciparum resistance to artemisinin-based combination therapy (ACT) is a global threat to malaria control and elimination efforts. Mutations in the P. falciparum kelch13 gene (Pfk13) that are associated [...] in other parts of PNG is unknown. We investigated the prevalence of Pfk13 mutations in multiple malaria-endemic regions of PNG. P. falciparum isolates (n = 1152) collected between 2016 and 2018 and assessed [...] Continued surveillance for molecular markers of drug resistance is...
Human exposure to anopheline mosquitoes occurs primarily indoors, even for users of insecticide-treated nets in Luangwa Valley, south-east Zambia (Publications)
insecticidal products. We studied the human biting behaviour of the malaria vector Anopheles funestus Giles and the potential malaria vector Anopheles quadriannulatus Theobald in Luangwa valley, south-east [...] ABSTRACT: BACKGROUND: Current front line malaria vector control methods such as indoor residual spraying (IRS) and long-lasting insecticidal nets (LLINs), rely upon the preference of many primary vectors
Access to artemisinin-based anti-malarial treatment and its related factors in rural Tanzania (Publications)
BACKGROUND: Artemisinin-based combination treatment (ACT) has been widely adopted as one of the main malaria control strategies. However, its promise to save thousands of lives in sub-Saharan Africa depends [...] of fever onset. In neither of the HDSS site was age, sex, socio-economic status or seasonality of malaria found to be significantly correlated with timely access. CONCLUSION: Timely access to authorized [...] major bottle neck and new more innovative interventions are needed to raise...
Costing RTS,S introduction in Burkina Faso, Ghana, Kenya, Senegal, Tanzania, and Uganda: a generalizable approach drawing on publicly available data (Publications)
Recent results from the phase 3 trial of RTS,S/AS01 malaria vaccine show that the vaccine induced partial protection against clinical malaria in infants and children; given the high burden of the disease [...] disease it is currently considered for use in malaria endemic countries. To inform adoption decisions the paper proposes a generalizable methodology to estimate the cost of vaccine introduction using routinely
Discovery and characterization of potent, efficacious, orally available antimalarial plasmepsin X inhibitors and preclinical safety assessment of... (Publications)
Plasmepsin X (PMX) is an essential aspartyl protease controlling malaria parasite egress and invasion of erythrocytes, development of functional liver merozoites (prophylactic activity), and blocking [...] days. This work demonstrates the potential to deliver PMX inhibitors with in vivo efficacy to treat malaria.
The catalytic subunit of <em>Plasmodium falciparum</em> casein kinase 2 is essential for gametocytogenesis (Publications)
pleiotropic kinase phosphorylating substrates in different cellular compartments in eukaryotes. In the malaria parasite Plasmodium falciparum, PfCK2 is vital for asexual proliferation of blood-stage parasites [...] PfCK2alpha catalytic subunit in gametocytes, the sexual forms of the parasite that are essential for malaria transmission. We show that PfCK2alpha localizes to the nucleus and cytoplasm in asexual and sexual