<em>Plasmodium falciparum </em>infection and clinical indicators in relation to net coverage in central Côte d'Ivoire (Publications)
Sleeping under a net, particularly a long-lasting insecticidal net (LLIN), is associated with reduced malaria morbidity and mortality, but requires high coverage and adherence. In this study, parasitologically [...] and associations with net coverage explored. In Bozi and Yoho, LLINs were provided by the national malaria control programme, prior to the study and an additional catch-up coverage was carried out in Bozi
The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - part I (Publications)
neglect of public awareness in high income countries. Another major tropical protozoan disease is malaria (caused by various Plasmodium species), which -although not mentioned currently by the WHO as a neglected [...] represents a major problem, especially to people living under poor circumstances in tropical countries. Malaria causes by far the highest number of deaths of all protozoan infections and is often (as in this review)
A 10 year study of the cause of death in children under 15 years in Manhica, Mozambique (Publications)
diseases accounted for 9.5% of the defined causes of death, and injuries for 3.9% of causes of deaths. Malaria was the single largest cause, accounting for 21.8% of cases. Pneumonia with 9.8% was the second leading [...] area. The pattern of childhood mortality in Manhica area is typical of developing countries where malaria, pneumonia and HIV/AIDS are important causes of death
Elimination of <em>Schistosoma mansoni</em> in infected mice by slow release of artemisone (Publications)
anti-plasmodial activity, and reduced toxicity compared to other artemisinins in clinical use against malaria. We infected adult mice by subcutaneous injection of S. mansoni cercariae (about 200) and treated [...] release of the artemisone that was verified in vivo and in vitro bioassays using drug-sensitive malaria parasites. We found superior strong anti-schistosome effects up to a total reduction of worm number
Multiplicity of <em>Plasmodium falciparum</em> infection following intermittent preventive treatment in infants (Publications)
Intermittent preventive treatment in infants with sulphadoxine-pyrimethamine (IPTi-SP) reduces malaria morbidity by 20% to 33%. Potentially, however, this intervention may compromise the acquisition of [...] of polyclonal infections (69.6% vs. 69.7%; P = 0.99). Adjusting for study site, current and prior malaria, parasite density, and season did not change this finding. CONCLUSIONS: IPTi-SP appears to have no
Safety and protective efficacy of PfSPZ vaccine administered to HIV negative and positive Tanzanian adults (Publications)
PfSPZ Vaccine, composed of attenuated Plasmodium falciparum (Pf) sporozoites (SPZ), protects against malaria. We conducted this clinical trial to assess the safety and efficacy of PfSPZ Vaccine in HIV positive [...] ts received 5 doses of PfSPZ Vaccine or normal saline over 28 days followed by controlled human malaria infection (CHMI) 3 weeks later. RESULTS: There were no solicited adverse events in the 9 HIV- and
New myxobacteria of the <em>Myxococcaceae</em> clade produce angiolams with antiparasitic activities (Publications)
named angiolams B, C, and D were found to display promising antiparasitic activities against the malaria pathogen Plasmodium falciparum in the 0.3-0.8 µM range.IMPORTANCEThe COVID-19 pandemic and continuously [...] diseases. However, the shortage of treatment options against protozoal parasitic infections, like malaria, is much more severe, especially for the treatment of so-called neglected tropical diseases. The
First detection of N1575Y mutation in pyrethroid resistant <em>Anopheles gambiae</em> in Southern Côte d'Ivoire (Publications)
insecticide classes is widespread. In an agricultural area of Southern Cote d'Ivoire, the main malaria vector Anopheles coluzzii shows multiple resistance across insecticides mediated by both target site [...] mutation in Cote d'Ivoire, and as in other populations, it is found in both dominant West African malaria vector species. Continued monitoring of N1575Y is underway, as are studies to elucidate its contribution
Very high carriage of gametocytes in asymptomatic low-density <em>Plasmodium falciparum</em> and <em>P. vivax</em> infections in western Thailand (Publications)
Plasmodium spp. are common in low endemicity areas worldwide, but outside Africa, their contribution to malaria transmission is poorly understood. Community-based studies with highly sensitive molecular diagnostics [...] gametocytes indicates that these infections may contribute substantially to the maintenance of local malaria transmission.
Can trials of spatial repellents be used to estimate mosquito movement? (Publications)
Knowledge of mosquito movement would aid the design of effective intervention strategies against malaria. However, data on mosquito movement through mark-recapture or genetics studies are challenging to [...] method may supplement those from mark-release-recapture studies, and be used in designing effective malaria intervention strategies, parameterizing mathematical models and in designing trials of vector control