Feasibility and acceptability of injectable artesunate for the treatment of severe malaria in the Democratic Republic of Congo (Publications)
The Democratic Republic of the Congo (DRC) changed its national policy for the treatment of severe malaria in both children and adults in 2012 from intravenous quinine to injectable artesunate. The country [...] deploy nationwide injectable artesunate as the preferred treatment for the management of severe malaria. To support this process, the feasibility and acceptability of the use of injectable artesunate in [...] CONCLUSIONS: These findings show that the use of injectable artesunate for the...
Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and... (Publications)
baseline values for clearance in patients from Sub-Saharan African countries with uncomplicated malaria treated with artemisinin-based combination therapies (ACTs). METHODS: A literature review in PubMed
Strategies and approaches to vector control in nine malaria-eliminating countries: a cross-case study analysis (Publications)
BACKGROUND: There has been progress towards malaria elimination in the last decade. In response, WHO launched the Global Technical Strategy (GTS), in which vector surveillance and control play important [...] important roles. Country experiences in the Eliminating Malaria Case Study Series were reviewed to identify success factors on the road to elimination using a cross-case study analytic approach. METHODS: Reports [...] Namibia, Philippines, Sri Lanka, Turkey, Turkmenistan). A conceptual...
Malaria transmission dynamics surrounding the first nationwide long-lasting insecticidal net distribution in Papua New Guinea (Publications)
BACKGROUND: The major malaria vectors of Papua New Guinea exhibit heterogeneities in distribution, biting behaviour and malaria infection levels. Long-lasting, insecticide-treated nets (LLINs), distributed [...] distributed as part of the National Malaria Control Programme, are the primary intervention targeting malaria transmission. This study evaluated the impact of LLINs on anopheline density, species composition [...] n, feeding behaviour, and malaria transmission. METHODS: Mosquitoes were...
The time-course of protection of the RTS,S vaccine against malaria infections and clinical disease (Publications)
BACKGROUND: Recent publications have reported follow-up of the RTS,S/AS01 malaria vaccine candidate Phase III trials at 11 African sites for 32 months (or longer). This includes site- and time-specific [...] Bayesian fitting of these model predictions to the site- and time-specific incidence of clinical malaria over 32 months (or longer) of follow-up. Using the same stochastic models, projections of clinical
Epidemiology of malaria in the Taabo health and demographic surveillance system, south-central Côte d'Ivoire (Publications)
epidemiology of malaria is essential for the design and implementation of setting-specific control and elimination efforts. In Cote d'Ivoire, new initiatives are underway to reduce the burden of malaria, which [...] which requires high-quality longitudinal data. The epidemiology of malaria was studied in the Taabo health and demographic surveillance system (HDSS) in south-central Cote d'Ivoire and implications for control [...] 6 and 62.8 % versus 42.6 and 51.2 %; respectively, in 2010 and 2011;...