Endlich: Die Malaria-Impfung kommt [TV Broadcast] (Publications)
"Bill Gates selbst gibt am Gates Malaria Forum in Seattle die bahnbrechende Nachricht bekannt: Erstmals im 100-jährigen Kampf gegen Malaria kann die Registrierung eines Impfstoffs eingeleitet werden. Schon [...] Schon bald können also Säuglinge in Malaria-Gebieten routinemässig gegen den lebensbedrohlichen Erreger geimpft und Millionen Menschenleben gerettet werden. Einer freut sich besonders über den Durchbruch: [...] Durchbruch: Der Schweizer Marcel Tanner, unermüdlicher Kämpfer gegen Malaria...
Encouraging impact following 2.5 years of reinforced malaria control interventions in a hyperendemic region of the Republic of Guinea (Publications)
multi-component malaria control intervention significantly reduced the prevalence of malaria in the sous-prefectures of intervention while also increasing the coverage of bed nets. However, malaria prevalence [...] BACKGROUND: Malaria is one of the principal causes of morbidity and mortality in the Republic of Guinea, particularly in the highly endemic regions. To assist in malaria control efforts, a multi-component [...] nent malaria control intervention was implemented in the hyperendemic...
Nanomimics of host cell membranes block invasion and expose invasive malaria parasites (Publications)
The fight against most infectious diseases, including malaria, is often hampered by the emergence of drug resistance and lack or limited efficacies of vaccines. Therefore, new drugs, vaccines, or other [...] ligands involved in the initial attachment to host cells and they efficiently blocked reinvasion of malaria parasites after their egress from host cells in vitro. They exhibited efficacies of more than 2 orders [...] infective parasite. In the future, our strategy might offer interesting...
Emulator-based Bayesian optimization for efficient multi-objective calibration of an individual-based model of malaria (Publications)
framework employing Gaussian process or machine learning emulator functions to calibrate a complex malaria transmission simulator. We demonstrate our approach by optimizing over a high-dimensional parameter [...] a portfolio of multiple fitting objectives built from datasets capturing the natural history of malaria transmission and disease progression. Our approach quickly outperforms previous calibrations, yielding
The 3-phosphoinositide-dependent protein kinase 1 is an essential upstream activator of protein kinase A in malaria parasites (Publications)
t protein kinase A (PKA) signalling is essential for the proliferation of Plasmodium falciparum malaria blood stage parasites. The mechanisms regulating the activity of the catalytic subunit PfPKAc, however [...] function has not been investigated in gametocytes, the sexual blood stage forms that are essential for malaria transmission. By studying a conditional PfPKAc knockdown (cKD) mutant, we confirm the essential role
Mapping the endemicity and seasonality of clinical malaria for intervention targeting in Haiti using routine case data (Publications)
Towards the goal of malaria elimination on Hispaniola, the National Malaria Control Program of Haiti and its international partner organisations are conducting a campaign of interventions targeted to high-risk
A stable, oligosymptomatic malaria focus in Thailand (Publications)
residents of a non-migratory farming village in south-eastern Thailand was visually examined for malaria parasites monthly for 2 years. Nearly 97% of the population had at least one (median = 5) patent [...] negative. The spleen rate (89% stage 1) was 24% in those under 15 years old and 7% in those older. No malaria mortality was seen P. falciparum cases treated for 10 d with quinine+tetracycline (QT) cleared the [...] better with MSP than with QT. The role played by hyperendemic, cryptic foci...