SiRENE - SiRENE - Short and Long Term Effects of Transportation Noise Exposure

Background: Little is known about how acute and short-term noise effects, especially those that are observed during sleep, translate into long-term health consequences. In particular, it is unclear which acoustical characteristics of noise from different traffic sources are most detrimental for human health and wellbeing.
Aims: The overall goal of this project is to investigate acute, short- and long-term effects of road, railway and aircraft noise exposure on annoyance, sleep disturbances and cardiometabolic risk. The project aims at identifying noise exposure patterns that most strongly affect individuals during sleep and thus may ultimately result in long-term health consequences. In addition, the role of individual characteristics such as age and gender, noise sensitivity and genetic predispositions will be elucidated. Methods: A nationwide assessment of road, railway and aircraft noise exposure will be conducted. In addition to average exposure, exposure modelling will be considerably refined to reflect additional exposure characteristics such as the degree of intermittence of noise events or the diurnal distribution of noise. During a one-week period in the sleep-laboratory, volunteers will be randomly exposed to different noise scenarios and effects on sleep as well as cardiometabolic parameters and subsequent cognitive performance will be investigated. Noise annoyance and coping responses in the Swiss population will be evaluated via a representative survey. Taking into account biomarkers and other factors including air pollution, data from two large on-going epidemiological studies (SAPALDIA Biobank and Swiss National Cohort) will be used to explore the exposure-response association for the various traffic noise sources and cardiometabolic morbidity and mortality. Significance: A key asset of this interdisciplinary study is the mutual combination of human experimental and epidemiological research to address acute, short- and long-term noise effects on sleep and cardiometabolic outcomes. Source-specific exposure-response functions will be determined giving due consideration to the acoustical characteristics of noise, such as the distribution of noise events during the night. This contribution to the understanding of health risks, especially for urban dwellers, and is highly relevant for regulating environmental noise.

Additional information: www.sirene-studie.ch

Brink M, Schäffer B, Vienneau D, Foraster M, Pieren R, Eze I.C, Cajochen C, Probst-Hensch N, Röösli M, Wunderli J.M. A survey on exposure-response relationships for road, rail, and aircraft noise annoyance: differences between continuous and intermittent noise. Environ Int. 2019;125:277-290. DOI: 10.1016/j.envint.2019.01.043

Brink M, Schaffer B, Vienneau D, Pieren R, Foraster M, Eze I.C, Rudzik F, Thiesse L, Cajochen C, Probst-Hensch N, Röösli M, Wunderli J.M. Self-reported sleep disturbance from road, rail and aircraft noise: exposure-response relationships and effect modifiers in the SiRENE Study. Int J Environ Res Public Health. 2019;16(21):4186. DOI: 10.3390/ijerph16214186

Brink M, Schreckenberg D, Vienneau D, Cajochen C, Wunderli J.M, Probst-Hensch N, Röösli M. Effects of scale, question location, order of response alternatives, and season on self-reported noise annoyance using ICBEN scales: a field experiment. Int J Environ Res Public Health. 2016;13(11):1163. DOI: 10.3390/ijerph13111163

Eze I.C, Foraster M, Schaffner E, Vienneau D, Héritier H, Pieren R, Thiesse L, Rudzik F, Rothe T, Pons M, Bettschart R, Schindler C, Cajochen C, Wunderli J.M, Brink M, Röösli M, Probst-Hensch N. Transportation noise exposure, noise annoyance and respiratory health in adults: a repeated-measures study. Environ Int. 2018;121(Pt 1):741-750. DOI: 10.1016/j.envint.2018.10.006

Eze I.C, Foraster M, Schaffner E, Vienneau D, Héritier H, Rudzik F, Thiesse L, Pieren R, Imboden M, von Eckardstein A, Schindler C, Brink M, Cajochen C, Wunderli J.M, Röösli M, Probst-Hensch N. Long-term exposure to transportation noise and air pollution in relation to incident diabetes in the SAPALDIA study. Int J Epidemiol. 2017;46(4):1115-1125. DOI: 10.1093/ije/dyx020

Eze I.C, Foraster M, Schaffner E, Vienneau D, Pieren R, Imboden M, Wunderli J.M, Cajochen C, Brink M, Röösli M, Probst-Hensch N. Incidence of depression in relation to transportation noise exposure and noise annoyance in the SAPALDIA study. Environ Int. 2020;144:106014. DOI: 10.1016/j.envint.2020.106014

Eze I.C, Imboden M, Foraster M, Schaffner E, Kumar A, Vienneau D, Héritier H, Rudzik F, Thiesse L, Pieren R, von Eckardstein A, Schindler C, Brink M, Wunderli J.M, Cajochen C, Röösli M, Probst-Hensch N. Exposure to night-time traffic noise, melatonin-regulating gene variants and change in glycemia in adults. Int J Environ Res Public Health. 2017;14(12):E1492. DOI: 10.3390/ijerph14121492

Eze I.C, Jeong A, Schaffner E, Rezwan F.I, Ghantous A, Foraster M, Vienneau D, Kronenberg F, Herceg Z, Vineis P, Brink M, Wunderli J.M, Schindler C, Cajochen C, Röösli M, Holloway J.W, Imboden M, Probst-Hensch N. Genome-wide DNA methylation in peripheral blood and long-term exposure to source-specific transportation noise and air pollution: the SAPALDIA study. Environ Health Perspect. 2020;128(6):67003. DOI: 10.1289/EHP6174

Foraster M, Eze I.C, Schaffner E, Vienneau D, Héritier H, Endes S, Rudzik F, Thiesse L, Pieren R, Schindler C, Schmidt-Trucksäss A, Brink M, Cajochen C, Marc Wunderli J, Röösli M, Probst-Hensch N. Exposure to road, railway, and aircraft noise and arterial stiffness in the SAPALDIA study: annual average noise levels and temporal noise characteristics. Environ Health Perspect. 2017;125(9):097004. DOI: 10.1289/EHP1136

Foraster M, Eze I.C, Vienneau D, Brink M, Cajochen C, Caviezel S, Héritier H, Schaffner E, Schindler C, Wanner M, Wunderli J.M, Röösli M, Probst-Hensch N. Long-term transportation noise annoyance is associated with subsequent lower levels of physical activity. Environ Int. 2016;91:341-349. DOI: 10.1016/j.envint.2016.03.011

Foraster M, Eze I.C, Vienneau D, Schaffner E, Jeong A, Héritier H, Rudzik F, Thiesse L, Pieren R, Brink M, Cajochen C, Wunderli J.M, Röösli M, Probst-Hensch N. Long-term exposure to transportation noise and its association with adiposity markers and development of obesity. Environ Int. 2018;121(Pt 1):879-889. DOI: 10.1016/j.envint.2018.09.057

Héritier H, Vienneau D, Foraster M, Eze I.C, Schaffner E, de Hoogh K, Thiesse L, Rudzik F, Habermacher M, Köpfli M, Pieren R, Brink M, Cajochen C, Wunderli J.M, Probst-Hensch N, Röösli M. A systematic analysis of mutual effects of transportation noise and air pollution exposure on myocardial infarction mortality: a nationwide cohort study in Switzerland. Eur Heart J. 2019;40(7):598-603. DOI: 10.1093/eurheartj/ehy650

Héritier H, Vienneau D, Foraster M, Eze I.C, Schaffner E, Thiesse L, Rudzik F, Habermacher M, Köpfli M, Pieren R, Brink M, Cajochen C, Wunderli J.M, Probst-Hensch N, Röösli M, SNC Study Group. Transportation noise exposure and cardiovascular mortality: a nationwide cohort study from Switzerland. Eur J Epidemiol. 2017;32(4):307-315. DOI: 10.1007/s10654-017-0234-2

Héritier H, Vienneau D, Foraster M, Eze I.C, Schaffner E, Thiesse L, Ruzdik F, Habermacher M, Köpfli M, Pieren R, Schmidt-Trucksäss A, Brink M, Cajochen C, Wunderli J.M, Probst-Hensch N, Röösli M, SNC study group. Diurnal variability of transportation noise exposure and cardiovascular mortality: a nationwide cohort study from Switzerland. Int J Hyg Environ Health. 2018;221(3):556-563. DOI: 10.1016/j.ijheh.2018.02.005

Héritier H, Vienneau D, Frei P, Eze I.C, Brink M, Probst-Hensch N, Röösli M. The association between road traffic noise exposure, annoyance and health-related quality of life (HRQOL). Int J Environ Res Public Health. 2014;11(12):12652-12667. DOI: 10.3390/ijerph111212652

Karipidis I, Vienneau D, Habermacher M, Köpfli M, Brink M, Probst-Hensch N, Röösli M, Wunderli J.M. Reconstruction of historical noise exposure data for environmental epidemiology in Switzerland within the SiRENE project. Noise Mapping. 2014;1(1):3-14. DOI: 10.2478/noise-2014-0002

Locher B, Piquerez A, Habermacher M, Ragettli M, Röösli M, Brink M, Cajochen C, Vienneau D, Foraster M, Müller U, Wunderli J.M. Differences between outdoor and indoor sound levels for open, tilted, and closed windows. Int J Environ Res Public Health. 2018;15(1):e149. DOI: 10.3390/ijerph15010149

Röösli M, Brink M, Rudzik F, Cajochen C, Ragettli M.S, Flückiger B, Pieren R, Vienneau D, Wunderli J.M. Associations of various nighttime noise exposure indicators with objective sleep efficiency and self-reported sleep quality: a field study. Int J Environ Res Public Health. 2019;16(20):E3790. DOI: 10.3390/ijerph16203790

Rudzik F, Thiesse L, Pieren R, Héritier H, Eze I.C, Foraster M, Vienneau D, Brink M, Wunderli J.M, Probst-Hensch N, Röösli M, Fulda S, Cajochen C. Ultradian modulation of cortical arousals during sleep: effects of age and exposure to nighttime transportation noise. Sleep. 2020;43(7):zsz324. DOI: 10.1093/sleep/zsz324

Thiesse L, Rudzik F, Kraemer J.F, Spiegel K, Leproult R, Wessel N, Pieren R, Héritier H, Eze I.C, Foraster M, Garbazza C, Vienneau D, Brink M, Wunderli J.M, Probst-Hensch N, Röösli M. Transportation noise impairs cardiovascular function without altering sleep: the importance of autonomic arousals. Environ Res. 2020;182:109086. DOI: 10.1016/j.envres.2019.109086

Thiesse L, Rudzik F, Spiegel K, Leproult R, Pieren R, Wunderli J.M, Foraster M, Héritier H, Eze I.C, Meyer M, Vienneau D, Brink M, Probst-Hensch N, Röösli M, Cajochen C. Adverse impact of nocturnal transportation noise on glucose regulation in healthy young adults: effect of different noise scenarios. Environ Int. 2018;121(1):1011-1023. DOI: 10.1016/j.envint.2018.05.036

Vienneau D, Héritier H, Foraster M, Eze I.C, Schaffner E, Thiesse L, Rudzik F, Habermacher M, Köpfli M, Pieren R, Brink M, Cajochen C, Wunderli J.M, Probst-Hensch N, Röösli M, SNC study Group. Façades, floors and maps – influence of exposure measurement error on the association between transportation noise and myocardial infarction. Environ Int. 2019;123:399-406. DOI: 10.1016/j.envint.2018.12.015

Wunderli J.M, Pieren R, Habermacher M, Vienneau D, Cajochen C, Probst-Hensch N, Röösli M, Brink M. Intermittency ratio: a metric reflecting short-term temporal variations of transportation noise exposure. J Expo Sci Environ Epidemiol. 2016;26(6):575-585. DOI: 10.1038/jes.2015.56

Vienneau D, de Hoogh K, Faeh D, Kaufmann M, Wunderli J.M, Röösli M, SNC Study Group. More than clean air and tranquillity: residential green is independently associated with decreasing mortality. Environ Int. 2017;108:176-184. DOI: 10.1016/j.envint.2017.08.012

Rudzik F, Thiesse L, Pieren R, Wunderli J.M, Brink M, Foraster M, Héritier H, Eze I.C, Garbazza C, Vienneau D, Probst-Hensch N, Röösli M, Cajochen C. Sleep spindle characteristics and arousability from night-time transportation noise exposure in healthy young and older individuals. Sleep. 2018;41(7):zsy077. DOI: 10.1093/sleep/zsy077

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