Further development of simulations of Plasmodium falciparum interventions and their integration with the needs of stakeholders II

This project supports the development and use of mathematical models for predicting the effects of different malaria interventions.  It is centered on contributions to the multi-group Bill and Melinda Gates Foundation Malaria Modeling Consortium (MMC). Specific areas additional to the MMC contributions are the analysis of threshold conditions for persistence of malaria, of residual transmission, of prioritization and targeting of interventions, and modeling of surveillance-response systems.

One important tool used in the project is the OpenMalaria open source (C++) microsimulation platform (http://github.com/SwissTPH/openmalaria/wiki). This software, developed by Swiss TPH, provides a general platform for modeling impacts on transmission and disease of different curative and preventive intervention strategies against Plasmodium falciparum (and P. vivax) on transmission and disease, considering different deployment options, and detailed product profiles.  It has been used to answer many different questions for product development, policy and intervention planning) including analyses of health systems, pharmacodynamics, and entomological interventions against malaria.