Publications

Keter A.K, Vanobberghen F, Lynen L, Van Heerden A, Fehr J, Olivier S, Wong E.B, Glass T.R, Reither K, Goetghebeur E, Jacobs B.K.M. Simultaneous alleviation of verification and reference standard biases in a community-based tuberculosis screening study using Bayesian latent class analysis. PLoS One. 2024;19(6):e0305126. DOI: 10.1371/journal.pone.0305126

Ndege R, Rohacek M, Bani F, Ngome O, Okuma J, Sasamalo M, Mnzava D, Reither K, Vanobberghen F, Hella J, Paris D.H, Weisser M. Diagnostic yield of urine Xpert MTB/RIF ultra in adults with suspected extrapulmonary tuberculosis. Open Forum Infect Dis. 2024;11(7):ofae338. DOI: 10.1093/ofid/ofae338

Vanobberghen F, Keter A.K, Jacobs B.K.M, Glass T.R, Lynen L, Law I, Murphy K, van Ginneken B, Ayakaka I, van Heerden A, Maama L, Reither K. Computer-aided detection thresholds for digital chest radiography interpretation in tuberculosis diagnostic algorithms. ERJ Open Res. 2024;10. DOI: 10.1183/23120541.00508-2023

Fuhr D.C, Sikander S, Vanobberghen F, Weobong B, Rahman A, Weiss H.A. Predictors of spontaneous remission and recovery among women with untreated perinatal depression in India and Pakistan. Glob Ment Health (Camb). 2023;10:e34. DOI: 10.1017/gmh.2023.26

Kalinjuma A.V, Glass T.R, Masanja H, Weisser M, Msengwa A.S, Vanobberghen F, Otwombe K. Statistical methods applied for the assessment of the HIV cascade and continuum of care: a systematic scoping review. BMJ Open. 2023;13(11):e071392. DOI: 10.1136/bmjopen-2022-071392

Kalinjuma A.V, Hussey H, Mollel G.J, Letang E, Battegay M, Glass T.R, Paris D, Vanobberghen F, Weisser M, KIULARCO study group. Body mass index trends and its impact of under and overweight on outcome among PLHIV on antiretroviral treatment in rural Tanzania: a prospective cohort study. PLoS One. 2023;18(8):e0290445. DOI: 10.1371/journal.pone.0290445

Mnzava D, Okuma J, Ndege R, Kimera N, Ntamatungiro A, Nyuri A, Byakuzana T, Abilahi F, Mayeka P, Temba E, Fanuel T, Glass T.R, Klimkait T, Vanobberghen F, Weisser M, KIULARCO Study Group. Decentralization of viral load testing to improve HIV care and treatment cascade in rural Tanzania: observational study from the Kilombero and Ulanga Antiretroviral Cohort. BMC Infect Dis. 2023;23:222. DOI: 10.1186/s12879-023-08155-6

Ndege R, Ngome O, Vanobberghen F, Bani F, Temba Y, Wilson H, Hella J, Gingo W, Sasamalo M, Mnzava D, Kimera N, Hiza H, Wigayi J, Mapesi H, Kato I.B, Mhimbira F, Reither K, Battegay M, Paris D.H, Weisser M, Rohacek M. Ultrasononography in managing extrapulmonary tuberculosis: a randomized, controlled, parallel, superiority, open-label trial. Clin Infect Dis. 2023;76(6):1013-1021. DOI: 10.1093/cid/ciac871

Ntamatungiro A.J, Eichenberger A, Okuma J, Vanobberghen F, Ndege R, Kimera N, Francis J.M, Kagura J, Weisser M, Kilombero and Ulanga Antiretroviral Cohort (KIULARCO) Study Group. Transitioning to dolutegravir in a programmatic setting: virological outcomes and associated factors among treatment-naive patients with HIV-1 in the Kilombero and Ulanga Antiretroviral Cohort in rural Tanzania. Open Forum Infect Dis. 2023;10(7):ofad321. DOI: 10.1093/ofid/ofad321

Magnolini R, Senkoro E, Kalinjuma A.V, Kitau O, Kivuma B, Samson L, Eichenberger A, Mollel G.J, Krinke E, Okuma J, Ndege R, Glass T, Mapesi H, Vanobberghen F, Battegay M, Weisser M. Stigma-directed services (Stig2Health) to improve 'linkage to care' for people living with HIV in rural Tanzania: study protocol for a nested pre-post implementation study within the Kilombero and Ulanga Antiretroviral Cohort. AAS Open Res. 2022;5:14. DOI: 10.12688/aasopenres.13353.2

Mollel G.J, Moshi L, Hazem H, Eichenberger A, Kitau O, Mapesi H, Glass T.R, Paris D.H, Weisser M, Vanobberghen F. Causes of death and associated factors over a decade of follow-up in a cohort of people living with HIV in rural Tanzania. BMC Infect Dis. 2022;22:37. DOI: 10.1186/s12879-021-06962-3

Ndege R.C, Okuma J, Kalinjuma A.V, Mkumbo J, Senkoro E, Fue G, Samson L, Mapesi H, Shabani S, Glass T.R, Battegay M, Paris D.H, Vanobberghen F, Weisser M, KIULARCO Study Group. Failure to return pillbox is a predictor of being lost to follow-up among people living with HIV on antiretroviral therapy in rural Tanzania. HIV Med. 2022;23(6):661-672. DOI: 10.1111/hiv.13223

Weisser M, Rohacek M, Ndege R, Luoga E, Katende A, Mollel G.J, Gingo W, Vanobberghen F, Paris D.H, Hatz C, Battegay M, on behalf of the Kiularco Study Group. The Chronic Diseases Clinic of Ifakara (CDCI): establishing a model clinic for chronic care delivery in rural sub-Saharan Africa. Diseases. 2022;10(4):72. DOI: 10.3390/diseases10040072

Brown J.A, Amstutz A, Nsakala B.L, Seeburg U, Vanobberghen F, Muhairwe J, Klimkait T, Daniel Labhardt N. Extensive drug resistance during low-level HIV viraemia while taking NNRTI-based ART supports lowering the viral load threshold for regimen switch in resource-limited settings: a pre-planned analysis from the SESOTHO trial. J Antimicrob Chemother. 2021;76(5):1294-1298. DOI: 10.1093/jac/dkab025

Kümmerle A, Sikalengo G, Vanobberghen F, Ndege R.C, Foe G, Schlaeppi C, Burri C, Battegay M, Paris D.H, Glass T.R, Weisser M, Marzolini C, Kiularco Study Group. Recognition and management of clinically significant drug-drug interactions between antiretrovirals and co-medications in a cohort of people living with HIV in rural Tanzania: a prospective questionnaire-based study. J Antimicrob Chemother. 2021;76(10):2681-2689. DOI: 10.1093/jac/dkab254

Magnolini R, Senkoro E, Vanobberghen F, Weisser M. "Linkage to care" among people living with HIV - definition in the era of "universal test and treat" in a sub-Sahara African setting. Swiss Med Wkly. 2021;151:w20535. DOI: 10.4414/smw.2021.20535

Mapesi H, Gupta R, Wilson H.I, Lukau B, Amstutz A, Lyimo A, Muhairwe J, Senkoro E, Byakuzana T, Mphunyane M, Bresser M, Glass T.R, Lambiris M, Fink G, Gingo W, Battegay M, Paris D.H, Rohacek M, Vanobberghen F, Labhardt N.D, Burkard T, Weisser M. The coArtHA trial—identifying the most effective treatment strategies to control arterial hypertension in sub-Saharan Africa: study protocol for a randomized controlled trial. Trials. 2021;22:77. DOI: 10.1186/s13063-021-05023-z

Mapesi H, Okuma J, Franzeck F, Wilson H.I, Senkoro E, Byakuzana T, Ndege R, Vanobberghen F, Glass T.R, Battegay M, Weisser M, Paris D.H, KIULARCO Study Group. Prevalence, incidence and predictors of renal impairment in persons with HIV receiving protease-inhibitors in rural Tanzania. PLoS One. 2021;16(12):e0261367. DOI: 10.1371/journal.pone.0261367

Mugglin C, Kläger D, Gueler A, Vanobberghen F, Rice B, Egger M, International epidemiology databases to evaluate AIDS in Southern Africa. The HIV care cascade in sub-Saharan Africa: systematic review of published criteria and definitions. J Int AIDS Soc. 2021;24(7):e25761. DOI: 10.1002/jia2.25761

Multerer L, Glass T.R, Vanobberghen F, Smith T. Analysis of contamination in cluster randomized trials of malaria interventions. Trials. 2021;22:613. DOI: 10.1186/s13063-021-05543-8

Multerer L, Vanobberghen F, Glass T.R, Hiscox A, Lindsay S.W, Takken W, Tiono A, Smith T. Estimating intervention effectiveness in trials of malaria interventions with contamination. Malar J. 2021;20:413. DOI: 10.1186/s12936-021-03924-7

Vanobberghen F, Lweno O, Kümmerle A, Mwebi K.D, Asilia P, Simon B, Mswata S, Schmidlin S, Glass T.R, Daubenberger C, Tanner M, Meyer-Monard S. Efficacy and safety of intravenous ferric carboxymaltose compared with oral iron for the treatment of iron deficiency anaemia in women after childbirth in Tanzania: a parallelgroup, open-label, randomised controlled phase 3 trial. Lancet Glob Health. 2021;9(2):e189-e198. DOI: 10.1016/S2214-109X(20)30448-4

Vanobberghen F, Weisser M, Kasuga B, Katende A, Battegay M, Tanner M, Glass T.R, KIULARCO Study Group. Mortality in a cohort of people living with HIV in rural Tanzania, accounting for unseen mortality among those lost to follow-up. Am J Epidemiol. 2021;190(2):251-264. DOI: 10.1093/aje/kwaa176

Amstutz A, Nsakala B.L, Vanobberghen F, Muhairwe J, Glass T.R, Namane T, Mpholo T, Battegay M, Klimkait T, Labhardt N.D. Switch to second-line versus continued first-line antiretroviral therapy for patients with low-level HIV-1 viremia: an open-label randomized controlled trial in Lesotho. PLoS Med. 2020;17(9):e1003325. DOI: 10.1371/journal.pmed.1003325

Kalinjuma A.V, Glass T.R, Weisser M, Myeya S.J, Kasuga B, Kisung'a Y, Sikalengo G, Katende A, Battegay M, Vanobberghen F, Kiularco Study Group. Prospective assessment of loss to follow-up: incidence and associated factors in a cohort of HIV-positive adults in rural Tanzania. J Int AIDS Soc. 2020;23(3):e25460. DOI: 10.1002/jia2.25460

Ndege R, Ngome O, Bani F, Temba Y, Wilson H, Vanobberghen F, Hella J, Gingo W, Sasamalo M, Mnzava D, Kimera N, Hiza H, Wigayi J, Mapesi H, Kato I.B, Mhimbira F, Reither K, Battegay M, Paris D.H, Weisser M, Rohacek M. Ultrasound in managing extrapulmonary tuberculosis: a randomized controlled two-center study. BMC Infect Dis. 2020;20:349. DOI: 10.1186/s12879-020-05073-9

Schlaeppi C, Vanobberghen F, Sikalengo G, Glass T.R, Ndege R.C, Foe G, Kümmerle A, Paris D.H, Battegay M, Marzolini C, Weisser M, Kilombero and Ulanga Antiretroviral Cohort (KIULARCO) study group. Prevalence and management of drug-drug interactions with antiretroviral treatment in 2069 people living with HIV in rural Tanzania: a prospective cohort study. HIV Med. 2020;21(1):53-63. DOI: 10.1111/hiv.12801

Vanobberghen F, Weiss H.A, Fuhr D.C, Sikander S, Afonso E, Ahmad I, Atif N, Bibi A, Bibi.T, Bilal S, de Sa A, D'Souza E, Joshi A, Korgaonkar P, Krishna R, Lazarus A, Liaqat R, Sharif M, Weobong B, Zaidi A, Zuliqar S, Patel V, Rahman A. Effectiveness of the Thinking Healthy Programme for perinatal depression delivered through peers: pooled analysis of two randomized controlled trials in India and Pakistan. J Affect Disord. 2020;265:660-668. DOI: 10.1016/j.jad.2019.11.110

Amstutz A, Lejone T.I, Khesa L, Muhairwe J, Nsakala B.L, Tlali K, Bresser M, Vanobberghen F, Kopo M, Kao M, Klimkait T, Battegay M, Labhardt N.D, Glass T.R. The HOSENG trial - effect of the provision of oral self-testing for absent and refusing individuals during a door-to-door HIV-testing campaign on testing coverage: protocol of a cluster-randomized clinical trial in rural Lesotho. Trials. 2019;20:496. DOI: 10.1186/s13063-019-3469-2

Glass T.R, Motaboli L, Nsakala B, Lerotholi M, Vanobberghen F, Amstutz A, Lejone T.I, Muhairwe J, Klimkait T, Labhardt N.D. The viral load monitoring cascade in a resource-limited setting: a prospective multicentre cohort study after introduction of routine viral load monitoring in rural Lesotho. PLoS One. 2019;14(8):e0220337. DOI: 10.1371/journal.pone.0220337

Meister I, Assawasuwannakit P, Vanobberghen F, Penny M, Odermatt P, Sayasone S, Huwyler J, Tarning J, Keiser J. Pooled population pharmacokinetic analysis of tribendimidine for the treatment of Opisthorchis viverrini infections. Antimicrob Agents Chemother. 2019;63(4):e01391-18. DOI: 10.1128/AAC.01391-18

Amstutz A, Nsakala B.L, Vanobberghen F, Muhairwe J, Glass T.R, Achieng B, Sepeka M, Tlali K, Sao L, Thin K, Klimkait T, Battegay M, Labhardt N.D. SESOTHO trial ("Switch Either near Suppression Or THOusand") - switch to second-line versus WHO-guided standard of care for unsuppressed patients on first-line ART with viremia below 1000 copies/mL: protocol of a multicenter, parallel-group, open-label, r. BMC Infect Dis. 2018;18:76. DOI: 10.1186/s12879-018-2979-y

Luoga E, Vanobberghen F, Bircher R, Nyuri A, Ntamatungiro A.J, Mnzava D, Mollel G.J, Letang E, Battegay M, Weisser M, Gamell A. No HIV transmission from virally suppressed mothers during breastfeeding in rural Tanzania. J Acquir Immune Defic Syndr. 2018;79(1):e17-e20. DOI: 10.1097/QAI.0000000000001758

Tiono A, Ouédraogo A, Ouattara D, Bougouma E.C, Coulibaly S, Diarra A, Faragher B, Guelbeogo M.W, Grisales N, Ouédraogo I.N, Ouédraogo Z.A, Pinder M, Sanon S, Smith T, Vanobberghen F, Sagnon N, Ranson H, Lindsay S.W. Efficacy of Olyset Duo, a bednet containing pyriproxyfen and permethrin, versus a permethrin-only net against clinical malaria in an area with highly pyrethroid-resistant vectors in rural Burkina Faso: a cluster-randomised controlled trial. Lancet. 2018;392(10147):569-580. DOI: 10.1016/S0140-6736(18)31711-2

Letang E, Verdastus Kalinjuma A, Glass T.R, Gamell A, Mapesi H, Sikalengo G.R, Luwanda L.B, Mnzava D, Ntamatungiro A.J, Ndaki R, Francis G, Vanobbergen F, Furrer H, Klimkait T, Felger I, Tanner M, Hatz C, Weisser M, Battegay M, KIULARCO Study Group. Cohort profile: the Kilombero and Ulanga Antiretroviral Cohort (KIULARCO): a prospective HIV cohort in rural Tanzania. Swiss Med Wkly. 2017;147:w14485. DOI: 10.4414/smw.2017.14485

Vanobberghen F, Letang E, Gamell A, Mnzava D.K, Faini D, Luwanda L.B, Mapesi H, Mwamelo K, Sikalengo G, Tanner M, Hatz C, Furrer H, Battegay M, Glass T.R, Kiularco Study Group. A decade of HIV care in rural Tanzania: trends in clinical outcomes and impact of clinic optimisation in an open, prospective cohort. PLoS One. 2017;12(7):e0180983. DOI: 10.1371/journal.pone.0180983

Meister I, Kovac J, Duthaler U, Odermatt P, Huwyler J, Vanobberghen F, Sayasone S, Keiser J. Pharmacokinetic study of praziquantel enantiomers and its main metabolite R-trans-4-OH-PZQ in plasma, blood and dried blood spots in Opisthorchis viverrini-infected patients. PLoS Negl Trop Dis. 2016;10(5):e0004700. DOI: 10.1371/journal.pntd.0004700

Vanobberghen F, Penny M.A, Duthaler U, Odermatt P, Sayasone S, Keiser J, Tarning J. Population pharmacokinetic modeling of tribendimidine metabolites in Opisthorchis viverrini-infected adults. Antimicrob Agents Chemother. 2016;60(10):5695-5704. DOI: 10.1128/AAC.00655-16

Meister I, Vanobberghen F, Penny M.A, Sayasone S, Phongluxa K, Odermatt P, Duthaler U, Leonidova A, Huwyler J, Keiser J. Population pharmacokinetics of the novel anthelminthic tribendimidine in Opisthorchis viverrini infected patients in Lao PDR. Trop Med Int Health, 2015;20(Suppl. 1):303. Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland

Vanobberghen F, Letang E, Gamell A, John A, Faini D, Bonaventure L, Mapesi H, Mwamelo K, Sikalengo G, Tanner M, Hatz C, Furrer H, Battegay M, Glass T. Challenges in estimating death and retention rates in a longitudinal cohort of HIV-infected persons in rural Tanzania. Trop Med Int Health, 2015;20(Suppl. 1):9. Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland

Chofle A.A, Jaka H, Koy M, Smart L.R, Kabangila R, Ewings F.M, Mazigo H.D, Johnson W.D, Fitzgerald D.W, Peck R.N, Downs J.A. Oesophageal varices, schistosomiasis, and mortality among patients admitted with haematemesis in Mwanza, Tanzania: a prospective cohort study. BMC Infect Dis. 2014;14:303. DOI: 10.1186/1471-2334-14-303

Ewings F.M, Ford D, Walker A.S, Carpenter J, Copas A. Optimal CD4 count for initiating HIV treatment: impact of CD4 observation frequency and grace periods, and performance of dynamic marginal structural models. Epidemiology. 2014;25(2):194-202. DOI: 10.1097/EDE.0000000000000043

Francis S.C, Ao T.T, Vanobberghen F.M, Chilongani J, Hashim R, Andreasen A, Watson-Jones D, Changalucha J, Kapiga S, Hayes R.J. Epidemiology of curable sexually transmitted infections among women at increased risk for HIV in northwestern Tanzania: inadequacy of syndromic management. PLoS One. 2014;9(7):e101221. DOI: 10.1371/journal.pone.0101221

Frater J, Ewings F, Hurst J, Brown H, Robinson N, Fidler S, Babiker A, Weber J, Porter K, Phillips R.E. HIV-1-specific CD4(+) responses in primary HIV-1 infection predict disease progression. AIDS. 2014;28(5):699-708. DOI: 10.1097/QAD.0000000000000130

Peck R, Mghamba J, Vanobberghen F, Kavishe B, Rugarabamu V, Smeeth L, Hayes R, Grosskurth H, Kapiga S. Preparedness of Tanzanian health facilities for outpatient primary care of hypertension and diabetes: a cross-sectional survey. Lancet Glob Health. 2014;2(5):e285-e292. DOI: 10.1016/S2214-109X(14)70033-6

Fidler S, Porter K, Ewings F, Frater J, Ramjee G, Cooper D, Rees H, Fisher M, Schechter M, Kaleebu P, Tambussi G, Kinloch S, Miro J.M, Kelleher A, McClure M, Kaye S, Gabriel M, Phillips R, Weber J, Babiker A. Short-course antiretroviral therapy in primary HIV infection. N Engl J Med. 2013;368(3):207-217. DOI: 10.1056/NEJMoa1110039

Kapiga S.H, Ewings F.M, Ao T, Chilongani J, Mongi A, Baisley K, Francis S, Andreasen A, Hashim R, Watson-Jones D, Changalucha J, Hayes R. The epidemiology of HIV and HSV-2 infections among women participating in microbicide and vaccine feasibility studies in Northern Tanzania. PLoS One. 2013;8(7):e68825. DOI: 10.1371/journal.pone.0068825

Njai H.F, Ewings F.M, Lyimo E, Foulongne V, Ngerageza D, Mongi A, Ssemwanga D, Andreasen A, Nyombi B, Ao T, Michael D, Urassa M, Todd J, Zaba B, Changalucha J, Hayes R, Kapiga S.H. Deciphering the complex distribution of human immunodeficiency virus type 1 subtypes among different cohorts in Northern Tanzania. PLoS One. 2013;8(12):e81848. DOI: 10.1371/journal.pone.0081848

Ewings F.M. Practical and theoretical considerations of the application of marginal structural models to estimate causal effects of treatment in HIV infection. London: University College London, 2012. Doctoral Thesis, Other Faculties

Hamlyn E, Ewings F.M, Porter K, Cooper D.A, Tambussi G, Schechter M, Pedersen C, Okulicz J.F, McClure M, Babiker A, Weber J, Fidler S. Plasma HIV viral rebound following protocol-indicated cessation of ART commenced in primary and chronic HIV infection. PLoS One. 2012;7(8):e43754. DOI: 10.1371/journal.pone.0043754

Burger D, Ewings F, Kabamba D, L'homme R, Mulenga V, Kankasa C, Thomason M, Gibb D.M, Chintu C, Walker A.S. Limited sampling models to predict the pharmacokinetics of nevirapine, stavudine, and lamivudine in HIV-infected children treated with pediatric fixed-dose combination tablets. Ther Drug Monit. 2010;32(3):369-372. DOI: 10.1097/FTD.0b013e3181d75e47

Ewings F.M, Bhaskaran K, McLean K, Hawkins D, Fisher M, Fidler S, Gilson R, Nock D, Brettle R, Johnson M, Phillips A, Porter K. Survival following HIV infection of a cohort followed up from seroconversion in the UK. AIDS. 2008;22(1):89-95. DOI: 10.1097/QAD.0b013e3282f3915e

L'homme R.F, Kabamba D, Ewings F.M, Mulenga V, Kankasa C, Thomason M.J, Walker A.S, Chintu C, Burger D.M, Gibb D.M. Nevirapine, stavudine and lamivudine pharmacokinetics in African children on paediatric fixed-dose combination tablets. AIDS. 2008;22(5):557-565. DOI: 10.1097/QAD.0b013e3282f4a208

Ellis J.C, L'homme R.F, Ewings F.M, Mulenga V, Bell F, Chileshe R, Molyneux E, Abernethy J, van Oosterhout J.J, Chintu C, Walker A.S, Gibb D.M, Burger D.M. Nevirapine concentrations in HIV-infected children treated with divided fixed-dose combination antiretroviral tablets in Malawi and Zambia. Antivir Ther. 2007;12(2):253-260