Publications

Bosman S, Ayakaka I, Muhairwe J, Kamele M, van Heerden A, Madonsela T, Labhardt N.D, Sommer G, Bremerich J, Zoller T, Murphy K, van Ginneken B, Keter A.K, Jacobs B.K.M, Bresser M, Signorell A, Glass T.R, Lynen L, Reither K. Evaluation of c-reactive protein and computer-aided analysis of chest x-rays as tuberculosis triage tests at health facilities in Lesotho and South Africa. Clin Infect Dis. 2024(in press). DOI: 10.1093/cid/ciae378

Bresser M, Erhardt R.M, Shanaube K, Simwinga M, Mahlatsi P.A, Belus J, Schaap A, Amstutz A, Gachie T, Glass T.R, Kangololo B, Mota J, Floyd S, Katende B, Klinkenberg E, Ayles H, Reither K, Ruperez M. Evaluation of COVID-19 antigen rapid diagnostic tests for self-testing in Lesotho and Zambia. PLoS One. 2024;19(2):e0280105. DOI: 10.1371/journal.pone.0280105

Centner C.M, Munir R, Tagliani E, Rieß F, Brown P, Hayes C, Dolby T, Zemanay W, Cirillo D.M, David A, Schumacher S.G, Denkinger C.M, Ruhwald M, Leukes V.N, Nicol M.P, Van der Walt I, Kisten G, Gumede M, Mace A, Brink A, Stevens W, Scott L, Penn-Nicholson A, Cox H, TB-CAPT Consortium. Reflex Xpert MTB/XDR testing of residual rifampicin-resistant specimens: a clinical laboratory-based diagnostic accuracy and feasibility study in South Africa. Open Forum Infect Dis. 2024;11(8):ofae437. DOI: 10.1093/ofid/ofae437

Geric C, Tavaziva G, Breuninger M, Dheda K, Esmail A, Scott A, Kagujje M, Muyoyeta M, Reither K, Khan A.J, Benedetti A, Khan F.A. Breaking the threshold: developing multivariable models using computer-aided chest X-ray analysis for tuberculosis triage. Int J Infect Dis. 2024;147:107221. DOI: 10.1016/j.ijid.2024.107221

Gils T, Hella J, Jacobs B.K.M, Sossen B, Mukoka M, Muyoyeta M, Nakabugo E, Van Nguyen H, Ubolyam S, Macé A, Vermeulen M, Nyangu S, Sanjase N, Sasamalo M, Dinh H.T, Ngo T.A, Manosuthi W, Jirajariyavej S, Denkinger C.M, Nguyen N.V, Avihingsanon A, Nakiyingi L, Székely R, Kerkhoff A.D, MacPherson P, Meintjes G, Reither K, Ruhwald M. A prospective evaluation of the diagnostic accuracy of the point-of-care VISITECT CD4 Advanced Disease test in seven countries. J Infect Dis. 2024(in press). DOI: 10.1093/infdis/jiae374

Gils T, Madonsela T, Kamele M, Ayakaka I, Van Heerden A, Vlieghe E, Bresser M, Decroo T, Lynen L, Reither K, Bosman S. Low tuberculosis treatment initiation after positive tuberculosis lipoarabinomannan results. ERJ Open Res. 2024;10(4). DOI: 10.1183/23120541.00182-2024

Hiza H, Zwyer M, Hella J, Arbués A, Sasamalo M, Borrell S, Xu Z.M, Ross A, Brites D, Fellay J, Reither K, Gagneux S, Portevin D. Bacterial diversity dominates variable macrophage responses of tuberculosis patients in Tanzania. Sci Rep. 2024;14(1):9287. DOI: 10.1038/s41598-024-60001-0

Keter A.K, Vanobberghen F, Lynen L, Van Heerden A, Fehr J, Olivier S, Wong E.B, Glass T.R, Reither K, Goetghebeur E, Jacobs B.K.M. Simultaneous alleviation of verification and reference standard biases in a community-based tuberculosis screening study using Bayesian latent class analysis. PLoS One. 2024;19(6):e0305126. DOI: 10.1371/journal.pone.0305126

Mangu C, Cossa M, Ndege R, Khosa C, Leukes V, de la Torre-Pérez L, Machiana A, Kivuma B, Mnzava D, Zachariah C, Manjate P, Tagliani E, Schacht C, Buech J, Singh S, Ehrlich J, Riess F, Sanz S, Kranzer K, Cox H, Sabi I, Nguenha D, Meggi B, Weisser M, Ntinginya N, Schumacher S, Ruhwald M, Penn-Nicholson A, Garcia-Basteiro A.L, TB-CAPT Consortium. Expanding Xpert MTB/RIF Ultra® and LF-LAM testing for diagnosis of tuberculosis among HIV-positive adults admitted to hospitals in Tanzania and Mozambique: a randomized controlled trial (the EXULTANT trial). BMC Infect Dis. 2024;24:831. DOI: 10.1186/s12879-024-09651-z

Ndege R, Rohacek M, Bani F, Ngome O, Okuma J, Sasamalo M, Mnzava D, Reither K, Vanobberghen F, Hella J, Paris D.H, Weisser M. Diagnostic yield of urine Xpert MTB/RIF ultra in adults with suspected extrapulmonary tuberculosis. Open Forum Infect Dis. 2024;11(7):ofae338. DOI: 10.1093/ofid/ofae338

Székely R, Sossen B, Mukoka M, Muyoyeta M, Nakabugo E, Hella J, Nguyen H.V, Ubolyam S, Chikamatsu K, Macé A, Vermeulen M, Centner C.M, Nyangu S, Sanjase N, Sasamalo M, Dinh H.T, Ngo T.A, Manosuthi W, Jirajariyavej S, Mitarai S, Nguyen N.V, Avihingsanon A, Reither K, Nakiyingi L, Kerkhoff A.D, MacPherson P, Meintjes G, Denkinger C.M, Ruhwald M, FujiLAM Study Consortium. Prospective multicentre accuracy evaluation of the FUJIFILM SILVAMP TB LAM test for the diagnosis of tuberculosis in people living with HIV demonstrates lot-to-lot variability. PLoS One. 2024;19(5):e0303846. DOI: 10.1371/journal.pone.0303846

Tschan Y, Sasamalo M, Hiza H, Fellay J, Gagneux S, Reither K, Hella J, Portevin D. Diagnostic accuracy of a sequence-specific Mtb-DNA hybridization assay in urine: a case-control study including subclinical TB cases. Microbiol Spectr. 2024;12(6):e0042624. DOI: 10.1128/spectrum.00426-24

Vanobberghen F, Keter A.K, Jacobs B.K.M, Glass T.R, Lynen L, Law I, Murphy K, van Ginneken B, Ayakaka I, van Heerden A, Maama L, Reither K. Computer-aided detection thresholds for digital chest radiography interpretation in tuberculosis diagnostic algorithms. ERJ Open Res. 2024;10. DOI: 10.1183/23120541.00508-2023

Gils T, Kamele M, Madonsela T, Bosman S, Ngubane T, Joseph P, Reither K, Bresser M, Vlieghe E, Decroo T, Ayakaka I, Lynen L, Van Heerden A. Implementation of the advanced HIV disease care package with point-of-care CD4 testing during tuberculosis case finding: a mixed-methods evaluation. PLoS One. 2023;18(12):e0296197. DOI: 10.1371/journal.pone.0296197

Glaser N, Bosman S, Madonsela T, van Heerden A, Mashaete K, Katende B, Ayakaka I, Murphy K, Signorell A, Lynen L, Bremerich J, Reither K. Incidental radiological findings during clinical tuberculosis screening in Lesotho and South Africa: a case series. J Med Case Rep. 2023;17(1):365. DOI: 10.1186/s13256-023-04097-4

Katende B, Bresser M, Kamele M, Chere L, Tlahali M, Erhardt R.M, Muhairwe J, Ayakaka I, Glass T.R, Ruhwald M, van Ginneken B, Murphy K, de Vos M, Amstutz A, Mareka M, Mooko S.M, Reither K, González Fernández L. Impact of a multi-disease integrated screening and diagnostic model for COVID-19, TB, and HIV in Lesotho. PLOS Glob Public Health. 2023;3(8):e0001488. DOI: 10.1371/journal.pgph.0001488

Keter A.K, Lynen L, Van Heerden A, Wong E, Reither K, Goetghebeur E, Jacobs B.K.M. Evaluation of tuberculosis diagnostic test accuracy using Bayesian latent class analysis in the presence of conditional dependence between the diagnostic tests used in a community-based tuberculosis screening study. PLoS One. 2023;18(3):e0282417. DOI: 10.1371/journal.pone.0282417

Klinkenberg E, Katende B, Ruperez M, Bresser M, Kangololo B, Bwalya J, Erhardt R.M, Schaap A, Kasese N, Gatchie T, Floyd S, Mota J, Ayles H, Shanaube K, Reither K. Creating access to SARS-CoV-2 screening and testing through community-based COVID-19 case-finding, observations from cross-sectional studies in Lesotho and Zambia. BMC Public Health. 2023;23:1414. DOI: 10.1186/s12889-023-16306-2

Labhardt N.D, González Fernández L, Katende B, Muhairwe J, Bresser M, Amstutz A, Glass T.R, Ruhwald M, Sacks J.A, Escadafal C, Mareka M, Mooko S.M, de Vos M, Reither K. Head-to-head comparison of nasal and nasopharyngeal sampling using SARS-CoV-2 rapid antigen testing in Lesotho. PLoS One. 2023;18(3):e0278653. DOI: 10.1371/journal.pone.0278653

Loiseau C, Windels E.M, Gygli S.M, Jugheli L, Maghradze N, Brites D, Ross A, Goig G, Reinhard M, Borrell S, Trauner A, Dötsch A, Aspindzelashvili R, Denes R, Reither K, Beisel C, Tukvadze N, Avaliani Z, Stadler T, Gagneux S. The relative transmission fitness of multidrug-resistant Mycobacterium tuberculosis in a drug resistance hotspot. Nat Commun. 2023;14:1988. DOI: 10.1038/s41467-023-37719-y

Murphy K, Muhairwe J, Schalekamp S, van Ginneken B, Ayakaka I, Mashaete K, Katende B, van Heerden A, Bosman S, Madonsela T, González Fernández L, Signorell A, Bresser M, Reither K, Glass T.R. COVID-19 screening in low resource settings using artificial intelligence for chest radiographs and point-of-care blood tests. Sci Rep. 2023;13:19692. DOI: 10.1038/s41598-023-46461-w

Ndege R, Ngome O, Vanobberghen F, Bani F, Temba Y, Wilson H, Hella J, Gingo W, Sasamalo M, Mnzava D, Kimera N, Hiza H, Wigayi J, Mapesi H, Kato I.B, Mhimbira F, Reither K, Battegay M, Paris D.H, Weisser M, Rohacek M. Ultrasononography in managing extrapulmonary tuberculosis: a randomized, controlled, parallel, superiority, open-label trial. Clin Infect Dis. 2023;76(6):1013-1021. DOI: 10.1093/cid/ciac871

Nooh F, Chernet A, Reither K, Okuma J, Brattig N.W, Utzinger J, Probst-Hensch N, Paris D.H, Dreyfus A. Prevalence of fever of unidentified aetiology in East African adolescents and adults: a systematic review and meta-analysis. Infect Dis Poverty. 2023;12:55. DOI: 10.1186/s40249-023-01105-z

Ntinginya N.E, Bakuli A, Mapamba D, Sabiiti W, Kibiki G, Minja L.T, Kuchaka D, Reither K, Phillips P.P.J, Boeree M.J, Gillespie S.H, Hoelscher M, Heinrich N. Tuberculosis molecular bacterial load assay reveals early delayed bacterial killing in patients with relapse. Clin Infect Dis. 2023;76(3):e990-e994. DOI: 10.1093/cid/ciac445

Simwinga M, Mahlatsi P.A, Molale M, Witola G, Mshanga I, Katende B, Amstutz A, Reither K, Shanaube K, Motlomelo M, Bond V, Belus J.M. Facilitators and barriers to COVID-19 testing in community and clinical settings: lessons learned from Lesotho and Zambia. PLOS Glob Public Health. 2023;3(10):e0002430. DOI: 10.1371/journal.pgph.0002430

Zwyer M, Rutaihwa L.K, Windels E, Hella J, Menardo F, Sasamalo M, Sommer G, Schmülling L, Borrell S, Reinhard M, Dötsch A, Hiza H, Stritt C, Sikalengo G, Fenner L, De Jong B.C, Kato-Maeda M, Jugheli L, Ernst J.D, Niemann S, Jeljeli L, Ballif M, Egger M, Rakotosamimanana N, Yeboah-Manu D, Asare P, Malla B, Dou H.Y, Zetola N, Wilkinson R.J, Cox H, Carter E.J, Gnokoro J, Yotebieng M, Gotuzzo E, Abimiku A, Avihingsanon A, Xu Z.M, Fellay J, Portevin D, Reither K, Stadler T, Gagneux S, Brites D. Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania. PLoS Pathog. 2023;19(4):e1010893. DOI: 10.1371/journal.ppat.1010893

Gils T, Lynen L, Muhairwe J, Mashaete K, Lejone T.I, Joseph P, Ngubane T, Keter A.K, Reither K, van Heerden A. Feasibility of implementing the advanced HIV disease care package as part of community-based HIV/TB activities: a mixed-methods study protocol. BMJ Open. 2022;12(2):e057291. DOI: 10.1136/bmjopen-2021-057291

Hiza H, Hella J, Arbués A, Sasamalo M, Misana V, Fellay J, Gagneux S, Reither K, Portevin D. CD38 expression by antigen-specific CD4 t cells is significantly restored 5 months after treatment initiation independently of sputum bacterial load at the time of tuberculosis diagnosis. Front Med. 2022;9:821776. DOI: 10.3389/fmed.2022.821776

Katende B, González Fernández L, Muhairwe J, Glass T.R, Ayakaka I, Labhardt N.D, Ruhwald M, de Vos M, Bresser M, Reither K. Diagnosis of SARS-CoV-2 infection from breath: a proof-of-concept study. IJID Reg. 2022;5:163-164. DOI: 10.1016/j.ijregi.2022.10.007

Tavaziva G, Harris M, Abidi S.K, Geric C, Breuninger M, Dheda K, Esmail A, Muyoyeta M, Reither K, Majidulla A, Khan A.J, Campbell J.R, David P.M, Denkinger C, Miller C, Nathavitharana R, Pai M, Benedetti A, Khan F.A. Chest X-ray analysis with deep learning-based software as a triage test for pulmonary tuberculosis: an individual patient data meta-analysis of diagnostic accuracy. Clin Infect Dis. 2022;74(8):1390–1400. DOI: 10.1093/cid/ciab639

Xu Z.M, Rüeger S, Zwyer M, Brites D, Hiza H, Reinhard M, Rutaihwa L, Borrell S, Isihaka F, Temba H, Maroa T, Naftari R, Hella J, Sasamalo M, Reither K, Portevin D, Gagneux S, Fellay J. Using population-specific add-on polymorphisms to improve genotype imputation in underrepresented populations. PLoS Comput Biol. 2022;18(1):e1009628. DOI: 10.1371/journal.pcbi.1009628

Zoller T, Mfinanga E.H, Zumba T.B, Asilia P.J, Mutabazi E.M, Wimmersberger D, Mhimbira F, Haraka F, Reither K. Symptoms and functional limitations related to respiratory health and carbon monoxide poisoning in Tanzania: a cross sectional study. Environ Health. 2022;21:38. DOI: 10.1186/s12940-022-00847-x

Gygli S.M, Loiseau C, Jugheli L, Adamia N, Trauner A, Reinhard M, Ross A, Borrell S, Aspindzelashvili R, Maghradze N, Reither K, Beisel C, Tukvadze N, Avaliani Z, Gagneux S. Prisons as ecological drivers of fitness-compensated multidrug-resistant Mycobacterium tuberculosis. Nat Med. 2021;27:1171–1177. DOI: 10.1038/s41591-021-01358-x

Gygli S.M, Loiseau C, Jugheli L, Adamia N, Trauner A, Reinhard M, Ross A, Borrell S, Aspindzelashvili R, Maghradze N, Reither K, Beisel C, Tukvadze N, Avaliani Z, Gagneux S. Publisher Correction: Prisons as ecological drivers of fitness-compensated multidrug-resistant Mycobacterium tuberculosis. Nat Med. 2021;27(7):1308. DOI: 10.1038/s41591-021-01417-3

Haraka F, Kakolwa M, Schumacher S.G, Nathavitharana R.R, Denkinger C.M, Gagneux S, Reither K, Ross A. Impact of the diagnostic test Xpert MTB/RIF on patient outcomes for tuberculosis (Review). Cochrane Database Syst Rev. 2021;2021(4):CD012972. DOI: 10.1002/14651858.CD012972.pub2

Hiza H, Hella J, Arbués A, Magani B, Sasamalo M, Gagneux S, Reither K, Portevin D. Case-control diagnostic accuracy study of a non-sputum CD38-based TAM-TB test from a single milliliter of blood. Sci Rep. 2021;11(1):13190. DOI: 10.1101/2021.03.10.21253246

Hodel N.C, Hamad A, Reither K, Kasella I.M, Abdulla S, Schoetzau A, Hatz C.F.R, Mayr M. Comparison of two different semiquantitative urinary dipstick tests with albumin-to-creatinine ratio for screening and classification of albuminuria according to KDIGO. A diagnostic test study. Diagnostics. 2021;11(1):81. DOI: 10.3390/diagnostics11010081

Minja L.T, Hella J, Mbwambo J, Nyandindi C, Omary U.S, Levira F, Mpagama S, Shimwela M, Okuma J, Gagneux S, Bruce R.D, Reither K. High burden of tuberculosis infection and disease among people receiving medication-assisted treatment for substance use disorder in Tanzania. PLoS One. 2021;16(4):e0250038. DOI: 10.1371/journal.pone.0250038

Ticlla M.R, Hella J, Hiza H, Sasamalo M, Mhimbira F, Rutaihwa L.K, Droz S, Schaller S, Reither K, Hilty M, Comas I, Beisel C, Schmid C.D, Fenner L, Gagneux S. The sputum microbiome in pulmonary tuberculosis and its association with disease manifestations: a cross-sectional study. Front Microbiol. 2021;12:633396. DOI: 10.3389/fmicb.2021.633396

Arpagaus A, Franzeck F.C, Sikalengo G, Ndege R, Mnzava D, Rohacek M, Hella J, Reither K, Battegay M, Glass T.R, Paris D.H, Bani F, Rajab O.N, Weisser M, Kiularco Study Group. Extrapulmonary tuberculosis in HIV-infected patients in rural Tanzania: the prospective Kilombero and Ulanga antiretroviral cohort. PLoS One. 2020;15(3):e0229875. DOI: 10.1371/journal.pone.0229875