Publications

Billingsley P.F, Richie T.L, Abdulla S, Ondo'o Ayekaba M, Daubenberger C.A, Garcia G.A, Hoffman S.L. A paradigm for Africa-centric vaccine development in Equatorial Guinea. Trends Parasitol. 2024;40(5):362-366. DOI: 10.1016/j.pt.2024.03.005

Daubenberger C.A, Silva J.C. First-generation malaria vaccine successfully implemented in three African countries. Lancet. 2024;403(10437):1607-1609. DOI: 10.1016/s0140-6736(23)02892-1

Foglierini M, Nortier P, Schelling R, Winiger R.R, Jacquet P, O'Dell S, Demurtas D, Mpina M, Lweno O, Muller Y.D, Petrovas C, Daubenberger C, Perreau M, Doria-Rose N.A, Gottardo R, Perez L. RAIN: machine learning-based identification for HIV-1 bNAbs. Nat Commun. 2024;15:5339. DOI: 10.1038/s41467-024-49676-1

Hosch S, Wagner P, Giger J.N, Dubach N, Saavedra E, Perno C.F, Gody J.C, Pagonendji M.S, Ngoagouni C, Ndoua C, Nsanzabana C, Vickos U, Daubenberger C, Schindler T. PHARE: a bioinformatics pipeline for compositional profiling of multiclonal Plasmodium falciparum infections from long-read Nanopore sequencing data. J Antimicrob Chemother. 2024;79(5):987-996. DOI: 10.1093/jac/dkae060

Jongo S, Church L.W.P, Milando F, Qassim M, Schindler T, Rashid M, Tumbo A, Nyaulingo G, Bakari B.M, Athuman Mbaga T, Mohamed L, Kassimu K, Simon B.S, Mpina M, Zaidi I, Duffy P.E, Swanson Ii P.A, Seder R, Herman J.D, Mendu M, Zur Y, Alter G, Kc N, Riyahi P, Abebe Y, Murshedkar T, James E.R, Billingsley P.F, Sim B.K.L, Richie T.L, Daubenberger C, Abdulla S, Hoffman S.L. Safety and protective efficacy of PfSPZ vaccine administered to HIV negative and positive Tanzanian adults. J Clin Invest. 2024;134(6):e169060. DOI: 10.1172/jci169060

Macià D, Campo J.J, Jairoce C, Mpina M, Sorgho H, Dosoo D, Agnandji S.T, Kusi K.A, Molinos-Albert L.M, Kariuki S, Daubenberger C, Mordmüller B, Moncunill G, Dobaño C. The effect of Plasmodium falciparum exposure and maternal anti-circumsporozoite protein antibodies on responses to RTS,S/AS01E vaccination in infants and children: an ancillary observational immunological study to a phase 3, randomised clinical t. Lancet Infect Dis. 2024(in press). DOI: 10.1016/s1473-3099(24)00527-9

Masoud N.S, Knopp S, Lenz N, Lweno O, Abdul Kibondo U, Mohamed A, Schindler T, Rothen J, Masimba J, S, Althaus F, Abdulla S, Tanner M, Daubenberger C, Genton B. The impact of soil transmitted helminth on malaria clinical presentation and treatment outcome: a case control study among children in Bagamoyo district, coastal region of Tanzania. PLoS Negl Trop Dis. 2024;18(8):e0012412. DOI: 10.1371/journal.pntd.0012412

Mitchell R.A, Macià D, Jairoce C, Mpina M, Naidu A, Chopo-Pizarro A, Vázquez-Santiago M, Campo J.J, Aide P, Aguilar R, Daubenberger C, Dobaño C, Moncunill G. Effect of RTS,S/AS01E vaccine booster dose on cellular immune responses in African infants and children. NPJ Vaccines. 2024;9:200. DOI: 10.1038/s41541-024-00977-y

Ren Y, Li C, Nanayakkara Sapugahawatte D, Zhu C, Spänig S, Jamrozy D, Rothen J, Daubenberger C.A, Bentley S.D, Ip M, Heider D. Predicting hosts and cross-species transmission of Streptococcus agalactiae by interpretable machine learning. Comput Biol Med. 2024;171:108185. DOI: 10.1016/j.compbiomed.2024.108185

Thomson-Luque R, Stabler T.C, Fürle K, Silva J.C, Daubenberger C. Plasmodium falciparum merozoite surface protein 1 as asexual blood stage malaria vaccine candidate. Expert Rev Vaccines. 2024;23(1):160-173. DOI: 10.1080/14760584.2023.2295430

Tumbo A, Lorenz F.R, Yang A.S.P, Sefried S, Schindler T, Mpina M, Dangy J.P, Milando F.A, Rashid M.A, Nyaulingo G, Ramadhani K, Jongo S, Felgner P.L, Abebe Y, Sim B.K.L, Church L.W.P, Richie T.L, Billingsley P.F, Murshedkar T, Hoffman S.L, Abdulla S, Kremsner P.G, Mordmüller B, Daubenberger C, Fendel R. PfSPZ Vaccine induces focused humoral immune response in HIV positive and negative Tanzanian adults. EBioMedicine. 2024;108:105364. DOI: 10.1016/j.ebiom.2024.105364

Abukhattab S, Hosch S, Abu-Rmeileh N.M.E, Hasan S, Vonäsch P, Crump L, Hattendorf J, Daubenberger C, Zinsstag J, Schindler T. Whole-genome sequencing for One Health surveillance of antimicrobial resistance in conflict zones: a case study of Salmonella spp. and Campylobacter spp. in the West Bank, Palestine. Appl Environ Microbiol. 2023;89(9):e00658-23. DOI: 10.1128/aem.00658-23

Banga R, Procopio F.A, Lana E, Gladkov G.T, Roseto I, Parsons E.M, Lian X, Armani-Tourret M, Bellefroid M, Gao C, Kauzlaric A, Foglierini M, Alfageme-Abello O, Sluka S.H.M, Munoz O, Mastrangelo A, Fenwick C, Muller Y, Mkindi C.G, Daubenberger C, Cavassini M, Trunfio R, Déglise S, Corpataux J.M, Delorenzi M, Lichterfeld M, Pantaleo G, Perreau M. Lymph node dendritic cells harbor inducible replication-competent HIV despite years of suppressive ART. Cell Host Microbe. 2023;31(10):1714-1731. DOI: 10.1016/j.chom.2023.08.020

Bechtold P, Wagner P, Hosch S, Gregorini M, Stark W.J, Gody J.C, Kodia-Lenguetama E.R, Pagonendji M.S, Donfack O.T, Phiri W.P, García G.A, Nsanzabana C, Daubenberger C.A, Schindler T, Vickos U. Development and evaluation of PlasmoPod: a cartridge-based nucleic acid amplification test for rapid malaria diagnosis and surveillance. PLOS Glob Public Health. 2023;3(9):e0001516. DOI: 10.1371/journal.pgph.0001516

Daubenberger C. Genetically modified malaria parasites as vaccine candidates. Trends Mol Med. 2023;29(1):1-3. DOI: 10.1016/j.molmed.2022.11.005

Jongo S.A, Urbano Nsue Ndong Nchama V, Church L.W.P, Olotu A, Manock S.R, Schindler T, Mtoro A, Kc N, Devinsky O, Zan E, Hamad A, Nyakarungu E, Mpina M, Deal A, Bijeri J.R, Ondo Mangue M.E, Ntutumu Pasialo B.E, Nguema G.N, Rivas M.R, Chemba M, Ramadhani K.K, James E.R, Stabler T.C, Abebe Y, Riyahi P, Saverino E.S, Sax J, Hosch S, Tumbo A, Gondwe L, Segura J.L, Falla C.C, Phiri W.P, Hergott D.E.B, García G.A, Maas C, Murshedkar T, Billingsley P.F, Tanner M, Ayekaba M.O, Sim B.K.L, Daubenberger C, Richie T.L, Abdulla S, Hoffman S.L. Safety and immunogenicity of radiation-attenuated PfSPZ vaccine in equatoguinean infants, children, and adults. Am J Trop Med Hyg. 2023;109(1):138-146. DOI: 10.4269/ajtmh.22-0773

Richie T.L, Church L.W.P, Murshedkar T, Billingsley P.F, James E.R, Chen M.C, Abebe Y, Natasha Kc, Chakravarty S, Dolberg D, Healy S.A, Diawara H, Sissoko M.S, Sagara I, Cook D.M, Epstein J.E, Mordmüller B, Kapulu M, Kreidenweiss A, Franke-Fayard B, Agnandji S.T, López Mikue M.A, McCall M.B.B, Steinhardt L, Oneko M, Olotu A, Vaughan A.M, Kublin J.G, Murphy S.C, Jongo S, Tanner M, Sirima S.B, Laurens M.B, Daubenberger C, Silva J.C, Lyke K.E, Janse C.J, Roestenberg M, Sauerwein R.W, Abdulla S, Dicko A, Kappe S.H.I, Sim B.K.L, Duffy P.E, Kremsner P.G, Hoffman S.L. Sporozoite immunization: innovative translational science to support the fight against malaria. Expert Rev Vaccines. 2023;22(1):964-1007. DOI: 10.1080/14760584.2023.2245890

Daubenberger C, Burrows J.N. Volunteer infection studies accelerate the clinical development of novel drugs against malaria. Lancet Infect Dis. 2022;22(6):753-754. DOI: 10.1016/S1473-3099(21)00679-4

Daubenberger C. Assessment of experimental malaria vaccine induced protection in pre-exposed populations. Lancet Infect Dis. 2022;22(3):305-307. DOI: 10.1016/S1473-3099(21)00359-5

Daubenberger C.A, Gupta R. Monoclonal antibodies for reducing malaria transmission. Lancet Infect Dis. 2022;22(11):1519-1520. DOI: 10.1016/S1473-3099(22)00413-3

Daubenberger C.A, Moncunill G. Next-generation malaria subunit vaccines to reduce disease burden in African children. Lancet Infect Dis. 2022;22(11):1655-1656. DOI: 10.1016/S1473-3099(22)00523-0

Hosch S, Mpina M, Nyakurungu E, Silochi Borico N, Obama T.M.A, Ovona M.C, Wagner P, Rubin S.E, Vickos U, Milang D.V.N, Ondo'o Ayekaba M, Phiri W.P, Daubenberger C.A, Schindler T. Genomic surveillance enables the identification of co-infections with multiple SARS-CoV-2 lineages in equatorial Guinea. Front Public Health. 2022;9:818401. DOI: 10.3389/fpubh.2021.818401

Hosch S, Yoboue C.A, Donfack O.T, Guirou E.A, Dangy J.P, Mpina M, Nyakurungu E, Blöchliger K, Guerra C.A, Phiri W.P, Ayekaba M.O, García G.A, Tanner M, Daubenberger C, Schindler T. Analysis of nucleic acids extracted from rapid diagnostic tests reveals a significant proportion of false positive test results associated with recent malaria treatment. Malar J. 2022;21:23. DOI: 10.1186/s12936-022-04043-7

Jongo S.A, Church L.W.P, Nchama Vunn, Hamad A, Chuquiyauri R, Kassim K.R, Athuman T, Deal A, Natasha K.C, Mtoro A, Mpina M, Nyakarungu E, Bidjimi G.O, Owono M.A, Maye E.R.M, Mangue M.E.O, Okomo G.N.N, Pasialo B.E.N, Mandumbi D.M.O, Mikue M.A.L, Mochomuemue F.L, Obono M.O, Besaha J.C.M, Bijeri J.R, Abegue G.M, Veri Y.R, Bela I.T, Chochi F.C, Lima Sánchez J.E, Pencelli V, Gayozo G, Nlang Jaem, Schindler T, James E.R, Abebe Y, Lemiale L, Stabler T.C, Murshedkar T, Chen M.C, Schwabe C, Ratsirarson J, Rivas M.R, Ayekaba M.O, Milang D.V.N, Falla C.C, Phiri W.P, Garcia G.A, Maas C.D, Nlavo B.M, Tanner M, Billingsley P.F, Kim Lee Sim B, Daubenberger C, Hoffman S.L, Abdulla S, Richie T.L. Multi-dose priming regimens of PfSPZ vaccine: safety and efficacy against controlled human malaria infection in Equatoguinean adults. Am J Trop Med Hyg. 2022;106(4):1215–1226. DOI: 10.4269/ajtmh.21-0942

Lebedin M, Foglierini M, Khorkova S, Vázquez García C, Ratswohl C, Davydov A.N, Turchaninova M.A, Daubenberger C, Chudakov D.M, Lanzavecchia A, de la Rosa K. Different classes of genomic inserts contribute to human antibody diversity. Proc Natl Acad Sci U S A. 2022;119(36):e2205470119. DOI: 10.1073/pnas.2205470119

Macià D, Campo J.J, Moncunill G, Jairoce C, Nhabomba A.J, Mpina M, Sorgho H, Dosoo D, Traore O, Kusi K.A, Williams N.A, Oberai A, Randall A, Sanz H, Valim C, Asante K.P, Owusu-Agyei S, Tinto H, Agnandji S.T, Kariuki S, Gyan B, Daubenberger C, Mordmüller B, Petrone P, Dobaño C. Strong off-target antibody reactivity to malarial antigens induced by RTS,S/AS01E vaccination is associated with protection. JCI Insight. 2022;7(10):e158030. DOI: 10.1172/jci.insight.158030

Manock S.R, Nsue V.U, Olotu A, Mpina M, Nyakarungu E, Raso J, Mtoro A, Ondo Mangue M.E, Ntutumu Pasialo B.E, Nguema R, Riyahi P, Schindler T, Daubenberger C, Church L.W.P, Billingsley P.F, Richie T.L, Abdulla S, Hoffman S.L. The impact of Loa loa microfilaraemia on research subject retention during a whole sporozoite malaria vaccine trial in Equatorial Guinea. Trans R Soc Trop Med Hyg. 2022;116(8):745-749. DOI: 10.1093/trstmh/trac019

Moncunill G, Carnes J, Chad Young W, Carpp L, De Rosa S, Campo J.J, Nhabomba A, Mpina M, Jairoce C, Finak G, Haas P, Muriel C, Van P, Sanz H, Dutta S, Mordmüller B, Agnandji S.T, Díez-Padrisa N, Williams N.A, Aponte J.J, Valim C, Neafsey D.E, Daubenberger C, McElrath M.J, Dobaño C, Stuart K, Gottardo R. Transcriptional correlates of malaria in RTS,S/AS01-vaccinated African children: a matched case-control study. eLife. 2022;11:e70393. DOI: 10.7554/eLife.70393

Mpina M, Stabler T.C, Schindler T, Raso J, Deal A, Acuche Pupu L, Nyakarungu E, Del Carmen Ovono Davis M, Urbano V, Mtoro A, Hamad A, Lopez M.S.A, Pasialo B, Eyang M.A.O, Rivas M.R, Falla C.C, Garcia G.A, Momo J.C, Chuquiyauri R, Saverino E, Preston Church L.W, Kim Lee Sim B, Manguire B, Tanner M, Maas C, Abdulla S, Billingsley P.F, Hoffman S.L, Jongo S, Richie T.L, Daubenberger C.A. Diagnostic performance and comparison of ultrasensitive and conventional rapid diagnostic test, thick blood smear and quantitative PCR for detection of low-density Plasmodium falciparum infections during a controlled human malaria infection study. Malar J. 2022;21:99. DOI: 10.1186/s12936-022-04103-y

Stabler T.C, Dwivedi A, Shrestha B, Joshi S, Schindler T, Ouattara A, García G.A, Daubenberger C, Silva J.C. Gene Coverage Count and Classification (GC3): a locus sequence coverage assessment tool using short-read whole genome sequencing data, and its application to identify and classify histidine-rich protein 2 and 3 deletions in Plasmodium falciparum. Malar J. 2022;21:357. DOI: 10.1186/s12936-022-04376-3

Yoboue C.A, Hosch S, Donfack O.T, Guirou E.A, Nlavo B.M, Ayekaba M.O, Guerra C, Phiri W.P, Garcia G.A, Schindler T, Daubenberger C.A. Characterising co-infections with Plasmodium spp., Mansonella perstans or Loa loa in asymptomatic children, adults and elderly people living on Bioko Island using nucleic acids extracted from malaria rapid diagnostic tests. PLoS Negl Trop Dis. 2022;16(1):e0009798. DOI: 10.1371/journal.pntd.0009798

Bechtold P, Wagner P, Hosch S, Siegrist D, Ruiz-Serrano A, Gregorini M, Mpina M, Ondó F.A, Obama J, Ayekaba M.O, Engler O, Stark W.J, Daubenberger C.A, Schindler T. Rapid identification of SARS-CoV-2 variants of concern using a portable peakPCR platform. Anal Chem. 2021;93(49):16350-16359. DOI: 10.1021/acs.analchem.1c02368

Brunetti G, Padovani F, De Pastina A, Rotella C, Monahan Am, Hoffman S.L, Jongo S.A, Abdulla S, Corradin G, Pluschke G, Daubenberger C, Hegner M. Nanotechnological immunoassay for rapid label-free analysis of candidate malaria vaccines. Nanoscale. 2021;13(4):2338-2349. DOI: 10.1039/D0NR08083G

Chen Y, Xu K, Piccoli L, Foglierini M, Tan J, Jin W, Gorman J, Tsybovsky Y, Zhang B, Traore B, Silacci-Fregni C, Daubenberger C, Crompton P.D, Geiger R, Sallusto F, Kwong P.D, Lanzavecchia A. Structural basis of malaria RIFIN binding by LILRB1-containing antibodies. Nature. 2021(592):639–643. DOI: 10.1038/s41586-021-03378-6

Cuénod A, Wüthrich D, Seth-Smith H.M.B, Ott C, Gehringer C, Foucault F, Mouchet R, Kassim A, Revathi G, Vogt D.R, von Felten S, Bassetti S, Tschudin-Sutter S, Hettich T, Schlotterbeck G, Homberger C, Casanova C, Moran-Gilad J, Sagi O, Rodriguez-Sanchez B, Muller F, Aerni M, Gaia V, van Dessel H, Kampinga G.A, Müller C, Daubenberger C, Pflüger V, Egli A. Whole-genome sequence-informed MALDI-TOF MS diagnostics reveal importance of Klebsiella oxytoca group in invasive infections: a retrospective clinical study. Genome Med. 2021;13:150. DOI: 10.1186/s13073-021-00960-5

Duffy F.J, Du Y, Carnes J, Epstein J.E, Hoffman S.L, Abdulla S, Jongo S, Mpina M, Daubenberger C, Aitchison J.D, Stuart K. Early whole blood transcriptional responses to radiation-attenuated Plasmodium falciparum sporozoite vaccination in malaria naive and malaria pre-exposed adult volunteers. Malar J. 2021;20:308. DOI: 10.1186/s12936-021-03839-3

Fink G, Orlova-Fink N, Schindler T, Grisi S, Ferrer A.P.S, Daubenberger C, Brentani A. Inactivated trivalent influenza vaccination is associated with lower mortality among patients with COVID-19 in Brazil. BMJ Evid Based Med. 2021;26(4):192-193. DOI: 10.1136/bmjebm-2020-111549

Jongo S.A, Urbano V, Church L.W.P, Olotu A, Manock S.R, Schindler T, Mtoro A, Kc N, Hamad A, Nyakarungu E, Mpina M, Deal A, Bijeri J.R, Ondo Mangue M.E, Ntutumu Pasialo B.E, Nguema G.N, Owono S.N, Rivas M.R, Chemba M, Kassim K.R, James E.R, Stabler T, Abebe Y, Saverino E, Sax J, Hosch S, Tumbo A.M, Gondwe L, Segura J.L, Falla C.C, Phiri W.P, Hergott D.E.B, Garcia G.A, Schwabe C, Maas C.D, Murshedkar T, Billingsley P.F, Tanner M, Ayekaba M.O, Sim B.K.L, Daubenberger C, Richie T.L, Abdulla S, Hoffman S.L. Immunogenicity and protective efficacy of radiation-attenuated and chemo-attenuated PfSPZ vaccines in Equatoguinean adults. Am J Trop Med Hyg. 2021;104(1):283-293. DOI: 10.4269/ajtmh.20-0435

Nchama Vunn, Said A.H, Mtoro A, Bidjimi G.O, Owono M.A, Maye E.R.M, Mangue M.E.O, Okomo G.N.N, Pasialo B.E.N, Ondo D.M, Lopez M.A, Mochomuemue F.L, Obono M.O, Besaha J.C.M, Chuquiyauri R, Jongo S.A, Kamaka K, Kibondo U.A, Athuman T, Falla C.C, Eyono J.N.M, Smith J.M, Garcia G.A, Raso J, Nyakarungu E, Mpina M, Schindler T, Daubenberger C, Lemiale L, Billingsley P.F, Sim B.K.L, Richie T.L, Church L.W.P, Olotu A, Tanner M, Hoffman S.L, Abdulla S. Incidence of Plasmodium falciparum malaria infection in 6-month to 45-year-olds on selected areas of Bioko Island, Equatorial Guinea. Malar J. 2021;20:322. DOI: 10.1186/s12936-021-03850-8

Oneko M, Steinhardt L.C, Yego R, Wiegand R.E, Swanson P.A, Kc N, Akach D, Sang T, Gutman J.R, Nzuu E.L, Dungani A, Kim Lee Sim B, Oloo P.N, Otieno K, Bii D.K, Billingsley P.F, James E.R, Kariuki S, Samuels A.M, Jongo S, Chebore W, Abdulla S, Daubenberger C, Mpina M, Styers D, Potter G.E, Abarbanell G, Richie T.L, Hoffman S.L, Seder R.A. Safety, immunogenicity and efficacy of PfSPZ vaccine against malaria in infants in western Kenya: a double-blind, randomized, placebo-controlled phase 2 trial. Nat Med. 2021;27(9):1636-1645. DOI: 10.1038/s41591-021-01470-y