Publications

Ren R, Leas D.A, Häberli C, Cal M, Chen G, Katneni K, Dong Y, Kaiser M, Keiser J, Charman S.A, Vennerstrom J.L. Medium-ring keto bislactams with antischistosomal activity. J Med Chem. 2024;67(20):18235-18246. DOI: 10.1021/acs.jmedchem.4c01532

Trometer N, Pecourneau J, Feng L, Navarro-Huerta J.A, Lazarin-Bidóia D, de Oliveira Silva Lautenschlager S, Maes L, Fortes Francisco A, Kelly J.M, Meunier B, Cal M, Mäser P, Kaiser M, Davioud-Charvet E. Synthesis and anti-Chagas activity profile of a redox-active Lead 3-benzylmenadione revealed by high-content imaging. ACS Infect Dis. 2024;10(5):1808-1838. DOI: 10.1021/acsinfecdis.4c00137

Vahekeni N, Brillatz T, Rahmaty M, Cal M, Keller-Märki S, Rocchetti R, Kaiser M, Sax S, Mattli K, Wolfram E, Marcourt L, Queiroz E.F, Wolfender J.L, Mäser P. Antiprotozoal activity of plants used in the management of sleeping sickness in Angola and bioactivity-guided fractionation of Brasenia schreberi J.F.Gmel and Nymphaea lotus L. Active against T. b rhodesiense. Molecules. 2024;29(7):1611. DOI: 10.3390/molecules29071611

Ren R, Wang X, Leas D.A, Scheurer C, Hövel S, Cal M, Chen G, Zhong L, Katneni K, Pham T, Patil R, Sil D, Walters M.J, Schulze T.T, Neville A.J, Dong Y, Wittlin S, Kaiser M, Davis P.H, Charman S.A, Vennerstrom J.L. Antimalarial dibenzannulated medium-ring keto lactams. ACS Infect Dis. 2023;9(10):1964-1980. DOI: 10.1021/acsinfecdis.3c00245

Ren R, Wang X, Leas D.A, Häberli C, Cal M, Dong Y, Kaiser M, Keiser J, Vennerstrom J.L. Antischistosomal tetrahydro-γ-carboline sulfonamides. Bioorg Med Chem Lett. 2022;59:128546. DOI: 10.1016/j.bmcl.2022.128546

Boberg M, Cal M, Kaiser M, Jansson-Lofmark R, Mäser P, Ashton M. Enantiospecific antitrypanosomal in vitro activity of eflornithine. PLoS Negl Trop Dis. 2021;15(7):e0009583. DOI: 10.1371/journal.pntd.0009583

Leas D.A, Sanford A.G, Wu J, Cal M, Kaiser M, Wittlin S, Hemsley R.M, Darner E.B, Lui L.M, Davis P.H, Vennerstrom J.L. Diaryl ureas as an antiprotozoal chemotype. ACS Infect Dis. 2021;7(6):1578-1583. DOI: 10.1021/acsinfecdis.1c00135

Rocha-Hasler M, de Oliveira G.M, da Gama A.N, Fiuza L.F.A, Fesser A.F, Cal M, Rocchetti R, Peres R.B, Guan X.L, Kaiser M, Soeiro M.N.C, Mäser P. Combination with tomatidine improves the potency of posaconazole against Trypanosoma cruzi. Front Cell Infect Microbiol. 2021;11:617917. DOI: 10.3389/fcimb.2021.617917

Hagen J.P, Darner G, Anderson S, Higgins K, Leas D.A, Mitra A, Mashinson V, Wol T, Vera-Esquivel C, Belter B, Cal M, Kaiser M, Wallick A, Warner R.C, Davis P.H. Activity of diphenyl ether benzyl amines against human African trypanosomiasis. Bioorg Chem. 2020;97:103590. DOI: 10.1016/j.bioorg.2020.103590

Wang X, Cal M, Kaiser M, Buckner F.S, Lepesheva G.I, Sanford A.G, Wallick A.I, Davis P.H, Vennerstrom J.L. A new chemotype with promise against Trypanosoma cruzi. Bioorg Med Chem Lett. 2020;30:126778. DOI: 10.1016/j.bmcl.2019.126778

Wiedemar N, Zwyer M, Zoltner M, Cal M, Field M.C, Mäser P. Expression of a specific variant surface glycoprotein has a major impact on suramin sensitivity and endocytosis in Trypanosoma brucei. FASEB Bioadv. 2019;1(10):595-608. DOI: 10.1096/fba.2019-00033

Wiedemar N, Graf F.E, Zwyer M, Ndomba E, Kunz Renggli C, Cal M, Schmidt R.S, Wenzler T, Mäser P. Beyond immune escape: a variant surface glycoprotein causes suramin resistance in Trypanosoma brucei. Mol Microbiol. 2018;107(1):57-67. DOI: 10.1111/mmi.13854

Cal M, Ioset J.R, Fügi M.A, Mäser P, Kaiser M. Assessing anti-T. cruzi candidates in vitro for sterile cidality. Int J Parasitol Drugs Drug Resist. 2016;6(3):165-170. DOI: 10.1016/j.ijpddr.2016.08.003

Cal M, Ioset J.R, Fügi M, Mäser P, Kaiser M. An in vitro assay to assess antichagasic candidates for sterile cure. Trop Med Int Health, 2015;20(Suppl. 1):335. Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland

Fesser A.F, Schmidt R.S, Mäser P, Cal M, Kaiser M. Stage-specific reporter gene expression in Trypanosoma cruzi. Trop Med Int Health, 2015;20(Suppl. 1):339. Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland

Wang X, Dong Y, Cal M, Kaiser M, Wittlin S, Vennerstrom J.L. Antiprotozoal selectivity of diimidazoline N-phenylbenzamides. ACS Infect Dis. 2015;1:135-139. DOI: 10.1021/id500034v

Dong Y, Wang X, Cal M, Kaiser M, Vennerstrom J.L. Activity of diimidazoline amides against African trypanosomiasis. Bioorg Med Chem Lett. 2014;24(3):944-948. DOI: 10.1016/j.bmcl.2013.12.064

Malebo H.M, Wenzler T, Cal M, Swaleh S.M, Hassanali A, Machocho A.K, Séquin U, Häussinger D, Dalsgaard P, Omolo M.O, Hamburger M, Brun R, Ndiege I.O. Anti-protozoal and structure-activity relationships of chemical constituents of Acridocarpus chloropterus Oliver (Malpighiaceae) from Tanzania. International Journal of Natural Products Research. 2013;3(4):74-81

Malebo H.M, Wenzler T, Cal M, Swaleh S.M, Omolo M.O, Hassanali A, Sequin U, Haussinger D, Dalsgaard P, Hamburger M, Brun R, Ndiege I.O. Anti-protozoal activity of aporphine and protoberberine alkaloids from Annickia kummeriae (Engl. & Diels) Setten & Maas (Annonaceae). BMC Complement Altern Med. 2013;13:48. DOI: 10.1186/1472-6882-13-48

Kaiser M, Bray M.A, Cal M, Trunz B.B, Torreele E, Brun R. Anti-trypanosomal activity of Fexinidazole: a new oral nitroimidazole drug candidate for the treatment of sleeping sickness. Antimicrob Agents Chemother. 2011;55(12):5602-5608. DOI: 10.1128/AAC.00246-11

Mokoka T.A, Zimmermann S, Julianti T, Hata Y, Moodley N, Cal M, Adams M, Kaiser M, Brun R, Koorbanally N, Hamburger M. In vitro screening of traditional South African malaria remedies against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum. Planta Med. 2011;77(14):1663-1667. DOI: 10.1055/s-0030-1270932

Malebo H.M, Wenzler T, Cal M, Swaleh S.A, Omolo M.O, Hassanali A, Sequin U, Hamburger M, Brun R, Ndiege I.O. Antiplasmodial, anti-trypanosomal, anti-leishmanial and cytotoxicity activity of selected Tanzanian medicinal plants. Tanzan J Health Res. 2009;11(4):226-234