Ribosomal protein S6 is hyper-activated and differentially phosphorylated in epidermal lesions of patients with psoriasis and atopic dermatitis (Publications)
BACKGROUND: The ribosomal protein S6 (S6) is part of the translation machinery and activated by phosphorylation via the mammalian target of rapamycin (mTOR) pathway, which is activated in psoriatic sk
The search for underlying principles of health impact assessment: progress and prospects: comment on "Investigating underlying principles to guide... (Publications)
Health Impact Assessment (HIA) is a relatively young field of endeavour, and hence, future progress will depend on the planning, implementation and rigorous evaluation of additional HIAs of projects,
Helminth products bypass the need for TSLP in Th2 immune responses by directly modulating dendritic cell function (Publications)
Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-7-like cytokine, mainly expressed by epithelial cells, and key to the development of allergic responses. The well-documented involvement of T
Lipidomics identifies a requirement for peroxisomal function during influenza virus replication (Publications)
Influenza virus acquires a host-derived lipid envelope during budding, yet a convergent view on the role of host lipid metabolism during infection is lacking. Using a mass spectrometry-based lipidomic
Baseline health conditions in selected communities of northern Sierra Leone as revealed by the health impact assessment of a biofuel project (Publications)
BACKGROUND: As biofuel projects may be associated with positive and negative effects on people's health and wellbeing, a health impact assessment was performed for the Addax Bioenergy Sierra Leone (AB
Pyridyl benzamides as a novel class of potent inhibitors for the kinetoplastid <em>Trypanosoma brucei</em> (Publications)
A whole-organism screen of approximately 87000 compounds against Trypanosoma brucei brucei identified a number of promising compounds for medicinal chemistry optimization. One of these classes of comp