Epidemiology of multiple<em> Plasmodium falciparum </em>infections. 4. Age dependence of the multiplicy of <em>Plasmodium falciparum</em> infections... (Publications)
The relationship between age and various malariological indices in the Kilombero valley of Tanzania were examined by compiling data from 6 different community studies carried out between 1989 and 1996
Lipidomics and genomics of <em>Mycobacterium tuberculosis</em> reveal lineage-specific trends in mycolic acid biosynthesis (Publications)
Mycolic acids (MAs) are alpha-alkyl, beta-hydroxy long-chain fatty acids found in abundance in the cell envelope of the Mycobacterium tuberculosis complex (MTBC). MAs form an efficient permeability ba
Blood schizontocidal and gametocytocidal activity of 3-hydroxy-N'-arylidenepropanehydrazonamides: a new class of antiplasmodial compounds (Publications)
3-Hydroxy-N'-arylidenepropanehydrazonamides represent a new class of antiplasmodial compounds. The two most active phenanthrene-based derivatives showed potent in vitro antiplasmodial activity against
Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives (Publications)
Sixty-two cationic benzyl phenyl ether derivatives (36 amidines and 26 prodrugs) were prepared and assayed for activities in vitro and in vivo against Trypanosoma brucei rhodesiense (STIB900), and in
Clinical aspects and management of cutaneous leishmaniasis in rheumatoid patients treated with TNF-a antagonists (Publications)
Patients under immunosuppressive therapy with tumor necrosis factor alpha (TNF-?) antagonists are vulnerable to various opportunistic infections including leishmaniasis. We present a case series of 8
Identification of a potential antimalarial drug candidate from a series of 2-aminopyrazines by optimization of aqueous solubility and potency across... (Publications)
Introduction of water-solubilizing groups on the 5-phenyl ring of a 2-aminopyrazine series led to the identification of highly potent compounds against the blood life-cycle stage of the human malaria
Directed synthesis of all four pure stereoisomers of the <em>N,C</em>-Coupled naphthylisoquinoline alkaloid ancistrocladinium A (Publications)
The first preparation of the N,C-coupled naphthylisoquinoline alkaloid ancistrocladinium A and its likewise naturally occurring minor atropisomer, in an atropisomerically pure form, is described. The