Female predominance and transmission distortion in the long-QT syndrome (Publications)
BACKGROUND: Congenital long-QT syndrome is a disorder resulting in ventricular arrhythmias and sudden death. The most common forms of the long-QT syndrome, types 1 and 2, are caused by mutations in th
Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of <em>Plasmodium falciparum</em> enoyl-ACP-reductase... (Publications)
Malaria, a disease of worldwide significance, is responsible for over one million deaths annually. The liver-stage of Plasmodium's life cycle is the first, obligatory, but clinically silent step in ma
Enhancing the usefulness of cross dehydrogenative coupling reactions with a removable protecting group (Publications)
A removable protecting group has been identified that allows the products of widely-used cross dehydrogenative couplings to be synthetically elaborated. The method can be used with enantiopure amines
Substituted 2-phenyl-imidazopyridines: a new class of drug leads for human African trypanosomiasis (Publications)
A phenotypic screen of a compound library for antiparasitic activity on Trypanosoma brucei, the causative agent of human African trypanosomiasis, led to the identification of substituted 2-(3-aminophe
Intergovernmental relations and long term care reforms: lessons from the Italian case (Publications)
The article aims at analysing the reasons why Italy failed to reform Long Term Care (LTC) policies, focusing on an aspect which has been overlooked: the interplay between LTC policies and the intergov
The prevalence and distribution of food sensitization in european adults (Publications)
BACKGROUND: Complaints of 'food allergy' are increasing. Standardized surveys of IgE sensitization to foods are still uncommon and multicountry surveys are rare. We have assessed IgE sensitization to
<em>In silico</em> prediction and experimental evaluation of furanoheliangolide sesquiterpene lactones as potent agents against <em>Trypanosoma brucei... (Publications)
In continuation of our earlier study on the in vitro antiprotozoal activity of 40 natural sesquiterpene lactones (STLs), we extended the set of tested compounds from our laboratories to 59. On the bas