New bis(2-aminoimidazoline) and bisguanidine DNA minor groove binders with potent in vivo antitrypanosomal and antiplasmodial activity (Publications)
A series of 75 guanidine and 2-aminoimidazoline analogue molecules were assayed in vitro against Trypanosoma brucei rhodesiense STIB900 and Plasmodium falciparum K1. The dicationic diphenyl compounds
Experience and lessons from health impact assessment guiding prevention and control of HIV/AIDS in a copper mine project, northwestern Zambia (Publications)
BACKGROUND: To avoid or mitigate potential project-related adverse health effects, the Trident copper project in Kalumbila, northwestern Zambia, commissioned a health impact assessment. HIV was identi
Urbanization is a main driver for the larval ecology of <em>Aedes</em> mosquitoes in arbovirus-endemic settings in south-eastern Côte d'Ivoire (Publications)
BACKGROUND: Failure in detecting naturally occurring breeding sites of Aedes mosquitoes can bias the conclusions drawn from field studies, and hence, negatively affect intervention outcomes. We charac
Draft genome sequences of seven <em>Streptococcus agalactiae </em>strains isolated from <em>Camelus dromedarius</em> at the Horn of Africa (Publications)
We present draft whole-genome sequences of seven Streptococcus agalactiae strains isolated from Camelus dromedarius in Kenya and Somalia. These data are an extension to the group B Streptococcus (GBS)
HIV viral load as an independent risk factor for tuberculosis in South Africa: collaborative analysis of cohort studies (Publications)
INTRODUCTION: Chronic immune activation due to ongoing HIV replication may lead to impaired immune responses against opportunistic infections such as tuberculosis (TB). We studied the role of HIV repl
Biobanking across the phenome - at the center of chronic disease research (Publications)
BACKGROUND: Recognized public health relevant risk factors such as obesity, physical inactivity, smoking or air pollution are common to many non-communicable diseases (NCDs). NCDs cluster and co-morbi
Longitudinal change of prebronchodilator spirometric obstruction and health outcomes: results from the SAPALDIA cohort (Publications)
Background Understanding the prognostic meaning of early stages of chronic obstructive pulmonary disease (COPD) in the general population is relevant for discussions about underdiagnosis. To date, COP
Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function (Publications)
In conducting genome-wide association studies (GWAS), analytic approaches leveraging biologic information may further understanding of the pathophysiology of clinical traits. To discover novel associa
Multiple loci associated with indices of renal function and chronic kidney disease (Publications)
Chronic kidney disease (CKD) has a heritable component and is an important global public health problem because of its high prevalence and morbidity. We conducted genome-wide association studies (GWAS