Long-term air pollution exposure and diabetes in a population-based Swiss cohort (Publications)
Air pollution is an important risk factor for global burden of disease. There has been recent interest in its possible role in the etiology of diabetes mellitus. Experimental evidence is suggestive, b
Adult onset asthma and interaction between genes and active tobacco smoking: the GABRIEL consortium (Publications)
BACKGROUND: Genome-wide association studies have identified novel genetic associations for asthma, but without taking into account the role of active tobacco smoking. This study aimed to identify nove
Genes interacting with occupational exposures to low molecular weight agents and irritants on adult-onset asthma in three European studies (Publications)
BACKGROUND: The biological mechanisms by which cleaning products and disinfectants - an emerging risk factor - affect respiratory health remain incompletely evaluated. Studying genes by environment in
Prevalence of renal impairment and its association with cardiovascular risk factors in a general population: results of the Swiss SAPALDIA study (Publications)
BACKGROUND: Impaired renal function is evolving as an independent marker of the risk of cardiovascular morbidity and mortality. Little is known about the prevalence of impaired renal function and its
Associations of novel and traditional vascular biomarkers of arterial stiffness: results of the SAPALDIA 3 cohort study (Publications)
BACKGROUND AND OBJECTIVES: There is a lack of evidence concerning associations between novel parameters of arterial stiffness as cardiovascular risk markers and traditional structural and functional v
Long-term exposure to ambient air pollution and metabolic syndrome in adults (Publications)
Air pollutants (AP) play a role in subclinical inflammation, and are associated with cardiovascular morbidity and mortality. Metabolic syndrome (MetS) is inflammatory and precedes cardiovascular morbi
Modifying effect of a common polymorphism in the interleukin-6 promoter on the relationship between long-term exposure to traffic-related particulate... (Publications)
BACKGROUND: Exposure to particulate matter (PM) has been associated with an increase in many inflammatory markers, including interleukin 6 (IL6). Air pollution exposure has also been suggested to indu
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function (Publications)
Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for est