ARMADA: using motif activity dynamics to infer gene regulatory networks from gene expression data (Publications)
Analysis of gene expression data remains one of the most promising avenues toward reconstructing genome-wide gene regulatory networks. However, the large dimensionality of the problem prohibits the fi
Prices and mark-ups on antimalarials: evidence from nationally representative studies in six malaria-endemic countries (Publications)
The private for-profit sector is an important source of treatment for malaria. However, private patients face high prices for the recommended treatment for uncomplicated malaria, artemisinin combinati
Community awareness, use and preference for pandemic influenza vaccines in Pune, India (Publications)
Vaccination is a cornerstone of influenza prevention, but limited vaccine uptake was a problem worldwide during the 2009-2010 pandemic. Community acceptance of a vaccine is a critical determinant of i
Understanding suicide attempts among gay men from their self-perceived causes (Publications)
Gay men are at higher risk of suicidality. This paper describes the causes of suicide attempts as perceived by the men themselves and analyzes their impact on severity and recidivism. Mental health su
Rapid shift toward overweight from double burden of underweight and overweight among Bangladeshi women: a systematic review and pooled analysis (Publications)
CONTEXT: Studies show there is a double burden of underweight and overweight in Bangladesh amidst a global background of increasing rates of overweight in low-income settings. OBJECTIVE: The aim of th
Intravenous artesunate reduces parasite clearance time, duration of intensive care and hospital treatment in patients with severe malaria in Europe:... (Publications)
Intravenous artesunate improves survival in severe malaria, but clinical trial data from non-endemic countries are scarce. The TropNet severe malaria database was analyzed to compare outcomes of artes
Co-option of membrane wounding enables virus penetration into cells (Publications)
During cell entry, non-enveloped viruses undergo partial uncoating to expose membrane lytic proteins for gaining access to the cytoplasm. We report that adenovirus uses membrane piercing to induce and
DNA replication fidelity in <em>Mycobacterium tuberculosis</em> is mediated by an ancestral prokaryotic proofreader (Publications)
The DNA replication machinery is an important target for antibiotic development in increasingly drug-resistant bacteria, including Mycobacterium tuberculosis. Although blocking DNA replication leads t