Aryl hydantoin Ro 13-3978, a broad-spectrum antischistosomal (Publications)
OBJECTIVES: Praziquantel is the only drug available for the treatment of schistosomiasis and the state of the exhausted drug discovery pipeline is alarming. We restarted investigations on the abandone
Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities (Publications)
Several of the enzymes related to the folate cycle are well-known for their role as clinically validated antimalarial targets. Nevertheless for serine hydroxymethyltransferase (SHMT), one of the key e
The WHO ultrasonography protocol for assessing morbidity due to <em>Schistosoma haematobium</em>: acceptance and evolution over 14 years: systematic... (Publications)
In 2000, the World Health Organization (WHO) published an ultrasound field protocol for assessing morbidity due to schistosomiasis. The present study aims to review the acceptance of the WHO protocol
Cost and sensitivity of on-farm versus slaughterhouse surveys for prevalence estimation and substantiating freedom from disease (Publications)
Within the framework of Swiss surveillance for epizootic diseases, dairy cattle are sampled using bulk tank milk while non-dairy cattle are sampled on the farm. The latter method is costly, time-deman
Skin and soft tissue infections in intercontinental travellers and the import of multi-resistant <em>Staphylococcus aureus</em> to Europe (Publications)
Staphylococcus aureus is emerging globally. Treatment of infections is complicated by increasing antibiotic resistance. We collected clinical data and swabs of returnees with skin and soft tissue infe
Molecular epidemiology suggests Venezuela as the origin of the dengue outbreak in Madeira, Portugal in 2012-2013 (Publications)
An explosive epidemic occurred in Madeira Island (Portugal) from October 2012 to February 2013. Published data showed that Dengue virus type 1 DENV-1) introduced from South America was the incriminate
Co-evolution of <em>Mycobacterium tuberculosis</em> and <em>Homo sapiens</em> (Publications)
The causative agent of human tuberculosis (TB), Mycobacterium tuberculosis, is an obligate pathogen that evolved to exclusively persist in human populations. For M. tuberculosis to transmit from perso
Academic institutions and One Health: building capacity for transdisciplinary research approaches to address complex health issues at the... (Publications)
To improve health at the human, animal, and ecosystem interface, defined as One Health, training of researchers must transcend individual disciplines to develop a new process of collaboration. The tra