In vivo investigations of selected diamidine compounds against <em>Trypanosoma evansi</em> using a mouse model (Publications)
Surra is an animal pathogenic protozoan infection, caused by Trypanosoma evansi, that develops into a fatal wasting disease. Control measures rely on diagnosis and treatment. However, with the continu
<em>myo</em>-inositol uptake is essential for bulk inositol phospholipid but not glycosylphosphatidylinositol synthesis in <em>Trypanosoma brucei</em> (Publications)
myo-Inositol is an essential precursor for the production of inositol phosphates and inositol phospholipids in all eukaryotes. Intracellular myo-inositol is generated by de novo synthesis from glucose
Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridines (Publications)
In an effort to address potential cardiotoxicity liabilities identified with earlier frontrunner compounds, a number of new 3,5-diaryl-2-aminopyridine derivatives were synthesized. Several compounds e
SAR studies on azasterols as potential anti-trypanosomal and anti-leishmanial agents (Publications)
There is an urgent need for the development of new drugs for the treatment of neglected tropical diseases such as human African trypanosomiasis, Chagas disease and leishmaniasis. Azasterols, have been
Zoonotic emerging infectious disease in selected countries in Southeast Asia: insights from Ecohealth (Publications)
Most emerging diseases of humans originate in animals, and zoonotic emerging infectious diseases (EIDs) threaten human, animal, and environment health. We report on a scoping study to assess actors, l