Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase (Publications)
We report the discovery of novel uracil-based acyclic compounds as inhibitors of deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase), an enzyme involved in nucleotide metabolism that has been i
Novel inhibitors of leishmanial dihydrofolate reductase (Publications)
The program DOCK3.5 was used to search the Cambridge Structural Database for novel inhibitors of Leishmanial dihydrofolate reductase. A number of compounds were obtained and screened against the enzym
Quinuclidine derivatives as potential antiparasitics (Publications)
There is an urgent need for the development of new drugs for the treatment of tropical parasitic diseases such as Chagas' disease and leishmaniasis. One potential drug target in the organisms that cau
Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase (Publications)
There is an urgent need for the development of new drugs to treat Chagas' disease, which is caused by the protozoan parasite Trypanosoma cruzi. The enzyme dihydrofolate reductase (DHFR) has been a ver
Cost analysis of dialysis modalities in Italy (Publications)
This study analyses management and costs of dialysis in the Italian National Health Service (NHS). Information on efficacy and health-related quality of life (HRQOL) based on the existing literature a
Costs of diabetes: a methodological analysis of the literature (Publications)
OBJECTIVE: To review studies on the costs of diabetes and its complications through a scheme designed specifically for assessing the quality of cost-of-illness (COI) studies. DESIGN AND SETTING: The m