Structure-activity study of pentamidine analogues as antiprotozoal agents (Publications)
Diamidine 1 (pentamidine) and 65 analogues (2-66) have been tested for in vitro antiprotozoal activities against Trypanosoma brucei rhodesiense, Plasmodium falciparum, and Leishmania donovani, and for
Safety and efficacy of the RTS,S/AS01(E) candidate malaria vaccine given with expanded-programme-on-immunisation vaccines: 19 month follow-up of a... (Publications)
BACKGROUND: The RTS,S/AS01(E) candidate malaria vaccine is being developed for immunisation of infants in Africa through the expanded programme on immunisation (EPI). 8 month follow-up data have been
3D QSAR on a library of heterocyclic diamidine derivatives with antiparasitic activity (Publications)
African trypanosomes, Trypanosoma brucei rhodesiense (TBR) and Trypanosoma brucei gambiense (TBG), affect hundreds of thousands of lives in tropical regions of the world. The toxicity of the diamidine
Identification of a new chemical class of antimalarials (Publications)
The increasing spread of drug-resistant malaria strains underscores the need for new antimalarial agents with novel modes of action (MOAs). Here, we describe a compound representative of a new class o
Growth of mature beech in relation to ozone and nitrogen deposition: an epidemiological approach (Publications)
Stem increment of mature Fagus sylvatica L. from 57 plots in Switzerland was analysed with respect to environmental factors using multilinear regression. Nitrogen (N) deposition was positively correla
The impact of obesity on mortality in UA/non-ST-segment elevation myocardial infarction (Publications)
AIMS: Obesity is associated with diabetes mellitus and advanced coronary artery disease (CAD). Once a non-ST-elevation acute coronary syndrome has occurred, the association between obesity and prognos
Phase change material for thermotherapy of Buruli ulcer: modelling as an aid to implementation (Publications)
A mathematical model was developed and validated to predict the thermal behaviour of a heat application device based on a phase change material (pcm) for the heat treatment of Mycobacterium ulcerans i