Synthesis and structure-activity analysis of new phosphonium salts with potent activity against African trypanosomes (Publications)
A series of 73 bisphosphonium salts and 10 monophosphonium salt derivatives were synthesized and tested in vitro against several wild type and resistant lines of Trypanosoma brucei (T. b. rhodesiense
Tolerability and efficacy of a pediatric granule formulation of artesunate-mefloquine in young children from Cameroon with uncomplicated falciparum... (Publications)
A fixed-dose pediatric formulation of artesunate and mefloquine (Artequin Pediatric) has been developed. In this open, non-comparative study in Cameroonian children with uncomplicated falciparum malar
Anti-protozoal and plasmodial FabI enzyme inhibiting metabolites of <em>Scrophularia lepidota</em> roots (Publications)
The ethanolic root extract of Scrophularia lepidota, an endemic plant of the Turkish flora, has been investigated for its anti-protozoal and inhibitory effect towards plasmodial enoyl-ACP reductase (F
MAGE-C1/CT-7 expression in plasma cell myeloma: sub-cellular localization impacts on clinical outcome (Publications)
Plasma cell myelomas (PMs) have a poor prognosis. Cancer-testis (CT) antigens are immunogenic proteins, representing potential targets for tumor vaccination strategies. The expression of the CT antige
Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis (Publications)
The choice of drugs for the treatment of sleeping sickness is extremely limited. To redress this situation, the recently synthesised diamidine, 2,5-bis(4-amidinophenyl)-furan (DB75, furamidine) and it
The distribution of <em>Biomphalaria</em> (Gastropoda: Planorbidae) in Lake Victoria with ecological and spatial predictions using Bayesian modelling (Publications)
Intestinal schistosomiasis is a global disease of enormous public health importance. Assessing the local risk of transmission of the parasite causing the disease requires an appraisal of the distribut