Tuberculosis treatment outcomes among HIV/TB-coinfected children in the International Epidemiology Databases to Evaluate AIDS (IeDEA) network (Publications)
INTRODUCTION: Management of tuberculosis (TB) is challenging in HIV/TB-coinfected children. The World Health Organization recommends nucleic acid amplification tests for TB diagnosis, a 4-drug regimen
Hit-to-lead optimization of a novel class of potent, broad-spectrum trypanosomacides (Publications)
The parasitic trypanosomes Trypanosoma brucei and T. cruzi are responsible for significant human suffering in the form of human African trypanosomiasis (HAT) and Chagas disease. Drugs currently availa
TbIRK is a signature sequence free potassium channel from <em>Trypanosoma brucei</em> locating to acidocalcisomes (Publications)
Potassium channels from prokaryotes and eukaryotes are usually recognized by a typical amino acid sequence TXTGY(F)G representing the ionic selectivity filter. Using a screening approach with ion chan
European Community Respiratory Health Survey II : final report of work package 6 : PM2.5 assessment in 21 European cities of ECRHS II (Publications)
The follow-up of a cohort of adults from 29 European centres of the former ECRHS I (1989-1992) will examine the long-term effects of exposure to ambient air pollution on the incidence, course, and pro
Cost description and comparative cost efficiency of post-exposure prophylaxis and canine mass vaccination against rabies in N'Djamena, Chad (Publications)
Rabies claims approximately 59,000 human lives annually and is a potential risk to 3.3 billion people in over 100 countries worldwide. Despite being fatal in almost 100% of cases, human rabies can be
Mosquito behavior change after distribution of bednets results in decreased protection against malaria exposure (Publications)
Background.: Behavioral resilience in mosquitoes poses a significant challenge to mosquito control. Although behavior changes in anopheline vectors have been reported over the last decade, there are n
Rapid diagnostic tests for non-malarial febrile illness in the tropics (Publications)
The recent roll-out of rapid diagnostic tests (RDTs) for malaria has highlighted the decreasing proportion of malaria-attributable illness in endemic areas. Unfortunately, once malaria is excluded, th